Kwon Hyuck Hoon, Choi Sun Chul, Park Kyung-Hoon, Jung Jae Yoon
Oaro Dermatology Clinic, Seoul, Korea.
Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
J Cosmet Dermatol. 2018 Jun;17(3):373-379. doi: 10.1111/jocd.12419. Epub 2017 Oct 12.
Intense focused ultrasound (IFUS) has demonstrated moderate efficacy for facial laxity of the aging face. Pressure- and dose-controlled transcutaneous pneumatic injections of hypertonic glucose solution (TPIG) are a minimally invasive way to deliver solution into the skin for therapeutic purposes. Recently, its application around temporal areas is known to exert early-onset lifting effects with facial contour rejuvenation.
We sought to evaluate the safety and efficacy of this novel combination regimen with IFUS and TPIG for lifting and tightening of aging face.
Twenty-two Korean subjects with mild-to-moderate facial skin laxity were evaluated after receiving a sequential single session of IFUS and TPIG treatments. Dermatologists' objective assessments for general appearance, and mid- and low faces based on photographic images were performed at 1- and 12-week post-treatment follow-ups. Patients' subjective assessments were also conducted. Skin biopsies were taken at baseline and the last visit.
Among 22 subjects, twenty (91%) demonstrated improvement after 12-week follow-up. We also observed similarly improved state just after 1 week of treatments (82%: 18/22). Specifically, improvement of the mid-face was evident from the first week, while the progress of the low face improvement was observed at the twelve week. Subjective assessments paralleled these findings. No seriously adverse effect was observed during procedures. Histologic evaluation showed greater dermal collagen fibers throughout the dermis after treatments.
Combination treatment with IFUS and TPIG has beneficial effects for skin lifting and tightening with early-onset time.
高强度聚焦超声（IFUS）已被证明对衰老面部的面部松弛有一定疗效。压力和剂量控制的经皮气动注射高渗葡萄糖溶液（TPIG）是一种将溶液输送到皮肤用于治疗目的的微创方法。最近，已知其在颞部区域周围的应用能产生早期提升效果并使面部轮廓年轻化。
我们试图评估这种IFUS和TPIG的新型联合方案用于提升和紧致衰老面部的安全性和有效性。
22名患有轻度至中度面部皮肤松弛的韩国受试者在接受了连续单次的IFUS和TPIG治疗后进行了评估。皮肤科医生在治疗后1周和12周的随访中，基于照片图像对整体外观以及中面部和下面部进行了客观评估。还进行了患者的主观评估。在基线和最后一次就诊时进行了皮肤活检。
在22名受试者中，20名（91%）在12周随访后显示出改善。我们还在治疗1周后观察到了类似的改善状态（82%：18/22）。具体而言，中面部从第一周开始就有明显改善，而下面部的改善进展在第十二周时观察到。主观评估与这些发现一致。在治疗过程中未观察到严重不良反应。组织学评估显示治疗后整个真皮层的真皮胶原纤维增多。
IFUS和TPIG联合治疗对皮肤提升和紧致有早期起效的有益效果。
