一种新型衣原体——TWAR与慢性冠心病和急性心肌梗死关联的血清学证据。
Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction.
作者信息
Saikku P, Leinonen M, Mattila K, Ekman M R, Nieminen M S, Mäkelä P H, Huttunen J K, Valtonen V
机构信息
Department of Virology, University of Helsinki, Finland.
出版信息
Lancet. 1988 Oct 29;2(8618):983-6. doi: 10.1016/s0140-6736(88)90741-6.
Paired sera from 40 male patients with acute myocardial infarction (AMI), 30 male patients with chronic coronary heart disease (CCHD), and 41 controls, matched for sex, age, time, and locality were investigated for antibodies to a novel type of Chlamydia sp, TWAR, and to chlamydial lipopolysaccharide (LPS) group antigen. 27 patients with AMI (68%), and 15 (50%) patients with CCHD had raised IgG (greater than or equal to 128) and/or IgA (greater than or equal to 32) titres in the microimmunofluorescence test with chlamydia TWAR. Both frequencies were significantly higher than in the controls (7, 17%). 26 (68%) of 38 patients with AMI also showed a significant seroconversion in enzyme immunoassay with LPS antigen; this response was absent in all patients with CCHD and all but 1 of the controls. Chronic chlamydial infection could be a factor in the pathogenesis of cardiovascular diseases.
对40例急性心肌梗死（AMI）男性患者、30例慢性冠心病（CCHD）男性患者以及41名在性别、年龄、时间和地点上相匹配的对照者的配对血清，检测了针对新型衣原体种——TWAR以及衣原体脂多糖（LPS）群抗原的抗体。在衣原体TWAR的微量免疫荧光试验中，27例AMI患者（68%）和15例CCHD患者（50%）的IgG（大于或等于128）和/或IgA（大于或等于32）滴度升高。这两个频率均显著高于对照组（7例，17%）。在38例AMI患者中，26例（68%）在LPS抗原的酶免疫测定中也显示出明显的血清学转换；所有CCHD患者以及除1例对照者外的所有对照者均无此反应。慢性衣原体感染可能是心血管疾病发病机制中的一个因素。
Zotero 插件