Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ann Nutr Metab. 2017;71(3-4):195-202. doi: 10.1159/000480711. Epub 2017 Oct 13.
Vitamin D is a multifunctional vitamin for our body. Type 2 diabetes mellitus (T2DM) is a common metabolic disease. Whether T2DM affects the serum 25(OH)D level has not been reported. The objective of this study was to reveal the extent to which vitamin D is present in the population in East China and to explore the relationship between serum 25(OH)D and T2DM.
The cohort was selected based on a large investigation named Survey on Prevalence in East China including 12,702 participants aged 21-92 years old. All the participants completed the questionnaire and went through a physical examination. Fasting blood samples were collected to test serum 25(OH)D and other metabolism-related indicators. AVONA was used to test the significance of differences among groups. Multinomial logistic regression was used to assess the association of T2DM with serum 25(OH)D level.
The overall percentage of vitamin D deficiency was 80.55% (male 74.1%, female 85.0%). Men with lower serum 25(OH)D level had high value in homeostasis model assessment of insulin resistance and HbA1c. The serum 25(OH)D level of those who were diagnosed with T2DM was higher than that in non-diabetics. The serum 25(OH)D level of pre-diabetes was the highest. T2DM patients trended to have higher serum 25(OH)D levels.
Vitamin D deficiency is common among the people in East-China. T2DM patients had higher levels of serum 25(OH)D. The relationship between vitamin D and T2DM is intriguing. It seemed that vitamin D was either irrelevant directly to T2DM or resisted in T2DM patients.
维生素 D 是人体的一种多功能维生素。2 型糖尿病（T2DM）是一种常见的代谢性疾病。T2DM 是否影响血清 25（OH）D 水平尚未报道。本研究的目的是揭示华东地区人群维生素 D 的含量，并探讨血清 25（OH）D 与 T2DM 的关系。
该队列是基于一项名为“华东地区流行情况调查”的大型调查中选择的，共纳入了 12702 名年龄在 21-92 岁的参与者。所有参与者都完成了问卷调查和体检。采集空腹血样检测血清 25（OH）D 和其他代谢相关指标。采用 AVONA 检验组间差异的显著性。采用多分类逻辑回归评估 T2DM 与血清 25（OH）D 水平的关系。
维生素 D 缺乏的总比例为 80.55%（男性 74.1%，女性 85.0%）。血清 25（OH）D 水平较低的男性，胰岛素抵抗和 HbA1c 的稳态模型评估值较高。诊断为 T2DM 的患者的血清 25（OH）D 水平高于非糖尿病患者。糖尿病前期患者的血清 25（OH）D 水平最高。T2DM 患者的血清 25（OH）D 水平呈上升趋势。
华东地区人群普遍存在维生素 D 缺乏。T2DM 患者的血清 25（OH）D 水平较高。维生素 D 与 T2DM 之间的关系令人关注。维生素 D 似乎与 T2DM 直接无关，或者在 T2DM 患者中具有抵抗力。
