Sun Xiaomin, Zhou Sirui, He Xin, Wang Youfa, Cui Wei
Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, Shaanxi 710061, China.
Department of Geriatric Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, Shaanxi 710061, China.
Int J Endocrinol. 2020 Jun 4;2020:9238719. doi: 10.1155/2020/9238719. eCollection 2020.
To evaluate the relationship between serum 25-hydroxyvitamin (25(OH)D) levels and metabolic risk factor levels in patients with type 2 diabetes mellitus (T2DM) on a sex-specific basis.
Our study comprised 507 patients with T2DM (321 men, 186 women; median age, 59 years). The metabolic risk factors examined included lipoprotein(a), glycated albumin (GA-L), and random blood glucose (RBG); the levels of these parameters were determined enzymatically. Serum 25(OH)D levels were measured by commercial ELISA kits. Participants were divided into low and high 25(OH)D groups according to the median 25(OH)D concentration (13.2 ng/mL). Two-way analysis of covariance and multiple linear regression analysis were performed.
The median 25(OH)D concentration was 13.9 ng/mL in men and 12.2 ng/mL in women. 25(OH)D levels inversely correlated with levels of three metabolic risk factors in a sex-dependent manner after adjusting for several confounding factors. These were lipoprotein(a) in men (141.3 ± 137.9 and 195.3 ± 204.8 mg/L in high and low 25(OH)D groups, respectively; < 0.05); GA-L in women (22.2 ± 8.8 vs. 23.3 ± 7.3% in high and low 25(OH)D groups, respectively; < 0.05). In a subgroup analysis, serum 25(OH)D levels inversely correlated with lipoprotein(a) levels in men ( = -0.185, = 0.002) and RBG levels in women ( = -0.176, = 0.028).
Higher serum 25(OH)D levels indicate a more favorable lipid profile in men and a more favorable glucose profile in women.
在2型糖尿病（T2DM）患者中，基于性别特异性评估血清25-羟基维生素（25(OH)D）水平与代谢危险因素水平之间的关系。
我们的研究纳入了507例T2DM患者（男性321例，女性186例；中位年龄59岁）。所检测的代谢危险因素包括脂蛋白(a)、糖化白蛋白（GA-L）和随机血糖（RBG）；这些参数的水平通过酶法测定。血清25(OH)D水平采用商用ELISA试剂盒进行检测。根据25(OH)D浓度中位数（13.2 ng/mL）将参与者分为25(OH)D低水平组和高水平组。进行了双向协方差分析和多元线性回归分析。
男性25(OH)D浓度中位数为13.9 ng/mL，女性为12.2 ng/mL。在调整了几个混杂因素后，25(OH)D水平以性别依赖的方式与三种代谢危险因素水平呈负相关。这些因素在男性中是脂蛋白(a)（25(OH)D高水平组和低水平组分别为141.3±137.9和195.3±204.8 mg/L；P<0.05）；在女性中是GA-L（25(OH)D高水平组和低水平组分别为22.2±8.8%和23.3±7.3%；P<0.05）。在亚组分析中，血清25(OH)D水平在男性中与脂蛋白(a)水平呈负相关（r=-0.185，P=0.002），在女性中与RBG水平呈负相关（r=-0.176，P=0.028）。
较高的血清25(OH)D水平表明男性的血脂谱更有利，女性的血糖谱更有利。
