促肾上腺皮质激素释放因子在大鼠束缚应激诱导的厌食症中的作用以及生长抑素对该厌食症的逆转作用。

Involvement of corticotropin-releasing factor in restraint stress-induced anorexia and reversion of the anorexia by somatostatin in the rat.

作者信息

Shibasaki T, Yamauchi N, Kato Y, Masuda A, Imaki T, Hotta M, Demura H, Oono H, Ling N, Shizume K

机构信息

Department of Medicine, Tokyo Women's Medical College, Japan.

出版信息

Life Sci. 1988;43(14):1103-10. doi: 10.1016/0024-3205(88)90468-7.

DOI:10.1016/0024-3205(88)90468-7

PMID:2902502

Abstract

The mechanism by which restraint stress induces suppression of food intake and the influence of intracerebroventricular (icv) administration of somatostatin on the anorexia induced by restraint stress were examined in the rat. Ninety minutes of restraint stress reduced food intake of rats to approximately 60% that of control. Anorexia induced by 90 min restraint stress was partially reversed by icv administration of alpha-helical CRF (9-41), a corticotropin-releasing factor (CRF) antagonist, and completely reversed by anti-CRF gamma-globulin. These results provide further evidence in support of the theory that CRF is involved in the inhibitory mechanism of food intake in restraint stress. ICV administration of somatostatin 14 and SMS 201-995, an analog of somatostatin, also reversed restraint stress-induced anorexia. It is, therefore, suggested that somatostatin may counteract the suppressive action of CRF on food intake in stress.

摘要

在大鼠中研究了束缚应激诱导食物摄入抑制的机制以及脑室内注射生长抑素对束缚应激诱导的厌食症的影响。90分钟的束缚应激使大鼠的食物摄入量减少至对照组的约60%。脑室内注射促肾上腺皮质激素释放因子（CRF）拮抗剂α-螺旋CRF（9-41）可部分逆转90分钟束缚应激诱导的厌食症，而抗CRFγ-球蛋白可完全逆转。这些结果为CRF参与束缚应激中食物摄入抑制机制的理论提供了进一步的证据。脑室内注射生长抑素14和生长抑素类似物SMS 201-995也可逆转束缚应激诱导的厌食症。因此，提示生长抑素可能抵消CRF在应激中对食物摄入的抑制作用。