State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
J Org Chem. 2017 Nov 3;82(21):11636-11643. doi: 10.1021/acs.joc.7b01947.
A novel copper(II) trifluoromethanesulfonate-catalyzed, high-efficiency, and atom-economical synthesis of valuable organophosphorus compounds via cascade annulation of propargylic alcohols with diphenylphosphine oxide is described. This protocol, which has a good functional-group compatibility and insensitivity to an ambient atmosphere, provides a simple and direct pathway to the products, organophosphorus compounds, in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus highlighting a potential application of this methodology.
一种新型的铜（II）三氟甲磺酸催化、高效、原子经济性的合成方法，通过炔丙醇与二苯膦氧化物的级联环化反应，合成有价值的有机磷化合物。该方法具有良好的官能团兼容性和对环境气氛不敏感的特点，在温和条件下以良好的产率提供了一种简单直接的产物，即有机磷化合物。该方法可以有效地放大到克级规模，因此突出了该方法的潜在应用。
