Mella Sara, Muzzatti Barbara, Dolcetti Riccardo, Annunziata Maria Antonietta
Unit of Oncological Psychology, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.
Cancer BioImmunotherapy Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.
Hered Cancer Clin Pract. 2017 Oct 2;15:16. doi: 10.1186/s13053-017-0077-6. eCollection 2017.
BRCA1 and BRCA2 mutations are associated with a higher risk of breast and ovarian tumors. This study evaluated the emotional states of women 1 month after having received the results of the genetic test and assessed eventual associations with the type of outcome, personal/familiar disease history and major socio-demographic variables.
The study, an observational retrospective one, involved 91 women, evaluated 1 month after receiving their results. Patients were administered the Hospital Anxiety and Depression Scale, the Profile of Mood States and emotional Thermometers.
Anxiety was significantly higher than depression ( < 0.001), and 21.3% and 21.3% of the sample were, respectively, possible and probable cases for anxiety, whereas 13.5% and 10.1% were possible and probable cases for depression. Within the six mood states, Confusion-Bewilderment (M = 48.5) was the lowest, whereas Fatigue-Inertia (M = 52.3) was the highest. Differences were recorded within the ten assessed emotions too. Being a proband/nonproband and being or not a cancer patient were associated with many tested variables.
The psycho-emotional screening of women undertaking genetic counseling is relevant and should cover a large range of dimensions.
BRCA1和BRCA2基因突变与乳腺癌和卵巢癌的较高风险相关。本研究评估了女性在收到基因检测结果1个月后的情绪状态，并评估了其与结果类型、个人/家族疾病史以及主要社会人口统计学变量之间的最终关联。
本研究为观察性回顾性研究，纳入了91名女性，在她们收到检测结果1个月后进行评估。对患者使用医院焦虑抑郁量表、情绪状态剖面图和情绪温度计进行评估。
焦虑显著高于抑郁（<0.001），样本中分别有21.3%和21.3%的人可能和很可能患有焦虑症，而有13.5%和10.1%的人可能和很可能患有抑郁症。在六种情绪状态中，困惑-迷茫（M = 48.5）得分最低，而疲劳-惰性（M = 52.3）得分最高。在评估的十种情绪中也记录到了差异。作为先证者/非先证者以及是否为癌症患者与许多测试变量相关。
对接受遗传咨询的女性进行心理情绪筛查具有重要意义，应涵盖广泛的维度。
