• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名儿童中枢神经系统CD1a阴性朗格汉斯细胞组织细胞增多症的罕见病例。

A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child.

作者信息

Powell Priscilla, Vitug Gaile, Castro-Silva Fernando, Ray Anish

机构信息

Weatherford Regional Medical Center Weatherford Texas.

University of Texas Health Science Center at San Antonio San Antonio Texas.

出版信息

Clin Case Rep. 2017 Sep 1;5(10):1664-1667. doi: 10.1002/ccr3.1136. eCollection 2017 Oct.

DOI:10.1002/ccr3.1136
PMID:29026568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628212/
Abstract

Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [, 126, 2015, 26 and , 331, 1994, 154].

摘要

朗格汉斯细胞组织细胞增多症是一种具有广泛严重程度和临床表现的树突状细胞疾病。组织病理学通常显示朗格汉斯细胞增殖以及伴有嗜酸性粒细胞的淋巴细胞组织细胞性炎性浸润。免疫组织化学检测细胞标志物S100、CD1a、CD68和朗格素支持该诊断[, 126, 2015, 26和, 331, 1994, 154]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5157/5628212/68879f1d303c/CCR3-5-1664-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5157/5628212/eca50cd90bc8/CCR3-5-1664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5157/5628212/68879f1d303c/CCR3-5-1664-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5157/5628212/eca50cd90bc8/CCR3-5-1664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5157/5628212/68879f1d303c/CCR3-5-1664-g002.jpg

相似文献

1
A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child.一名儿童中枢神经系统CD1a阴性朗格汉斯细胞组织细胞增多症的罕见病例。
Clin Case Rep. 2017 Sep 1;5(10):1664-1667. doi: 10.1002/ccr3.1136. eCollection 2017 Oct.
2
Bone marrow involvement of Langerhans cell histiocytosis: immunohistochemical evaluation of bone marrow for CD1a, Langerin, and S100 expression.朗格汉斯细胞组织细胞增生症的骨髓累及：骨髓中 CD1a、朗格汉斯蛋白和 S100 表达的免疫组化评估。
Histopathology. 2014 Dec;65(6):742-8. doi: 10.1111/his.12481. Epub 2014 Aug 19.
3
A Case of Uncommon S100-Negative CD1a-Positive Histiocytosis in a 9-Year-Old Boy: Clinical Presentation, Histopathologic Features, and Successful Treatment Approach.一例 9 岁男孩罕见的 S100 阴性 CD1a 阳性组织细胞增生症：临床表现、组织病理学特征和成功的治疗方法。
Am J Dermatopathol. 2024 Feb 1;46(2):121-125. doi: 10.1097/DAD.0000000000002602. Epub 2023 Dec 6.
4
Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders.朗格汉斯细胞组织细胞增多症和非朗格汉斯细胞组织细胞增生性疾病中Langerin的免疫组化表达
Am J Surg Pathol. 2008 Apr;32(4):615-9. doi: 10.1097/PAS.0b013e31815b212b.
5
Immunohistochemical analysis of langerin in langerhans cell histiocytosis and pulmonary inflammatory and infectious diseases.朗格汉斯细胞组织细胞增多症以及肺部炎症性和感染性疾病中朗格蛋白的免疫组织化学分析
Am J Surg Pathol. 2007 Jun;31(6):947-52. doi: 10.1097/01.pas.0000249443.82971.bb.
6
Clinical and immunohistochemical evaluation of the vulvar Langerhans cell histiocytosis.外阴朗格汉斯细胞组织细胞增多症的临床及免疫组化评估
Dermatol Ther. 2008 Nov-Dec;21 Suppl 3:S15-20. doi: 10.1111/j.1529-8019.2008.00236.x.
7
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.组织细胞和辅助性树突状细胞肿瘤：国际淋巴瘤研究组基于61例病例的免疫组织化学分类方法
Histopathology. 2002 Jul;41(1):1-29. doi: 10.1046/j.1365-2559.2002.01418.x.
8
S100-Negative, CD1a-Positive Cutaneous Histiocytosis in a Patient with S100-Positive, CD1a-Positive Pulmonary Histiocytosis.一名患有S100阳性、CD1a阳性肺组织细胞增多症的患者出现S100阴性、CD1a阳性皮肤组织细胞增多症。
Am J Dermatopathol. 2015 Aug;37(8):647-9. doi: 10.1097/DAD.0000000000000213.
9
Malignant Histiocytosis Comprises a Phenotypic Spectrum That Parallels the Lineage Differentiation of Monocytes, Macrophages, Dendritic Cells, and Langerhans Cells.恶性组织细胞增多症包含一个与单核细胞、巨噬细胞、树突状细胞和朗格汉斯细胞的谱系分化平行的表型谱。
Mod Pathol. 2023 Oct;36(10):100268. doi: 10.1016/j.modpat.2023.100268. Epub 2023 Jul 4.
10
Solitary cutaneous dendritic cell tumor in a child: role of dendritic cell markers for the diagnosis of skin Langerhans cell histiocytosis.
J Am Acad Dermatol. 2005 Nov;53(5):838-44. doi: 10.1016/j.jaad.2005.07.011.

引用本文的文献

1
Marking vertebrates langerhans cells, from fish to mammals.标记鱼类到哺乳动物的朗格汉斯细胞。
Acta Histochem. 2020 Oct;122(7):151622. doi: 10.1016/j.acthis.2020.151622. Epub 2020 Sep 9.
2
Patients with both Langerhans cell histiocytosis and Crohn's disease highlight a common role of interleukin-23.患有朗格汉斯细胞组织细胞增多症和克罗恩病的患者突出了白细胞介素-23的共同作用。
Acta Paediatr. 2021 Apr;110(4):1315-1321. doi: 10.1111/apa.15590. Epub 2020 Oct 8.

本文引用的文献

1
Histiocytic proliferations.组织细胞增殖
Semin Diagn Pathol. 2016 Nov;33(6):396-409. doi: 10.1053/j.semdp.2016.08.009. Epub 2016 Sep 1.
2
How I treat Langerhans cell histiocytosis.我如何治疗朗格汉斯细胞组织细胞增多症。
Blood. 2015 Jul 2;126(1):26-35. doi: 10.1182/blood-2014-12-569301. Epub 2015 Mar 31.
3
Pituitary stalk thickening in a case of langerhans cell histiocytosis.朗格汉斯细胞组织细胞增生症病例中的垂体柄增粗。
Arch Iran Med. 2015 Mar;18(3):193-5.
4
Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?朗格汉斯细胞组织细胞增多症发病机制的认识进展：回归组织细胞增生症X？
Br J Haematol. 2015 Apr;169(1):3-13. doi: 10.1111/bjh.13247. Epub 2014 Nov 28.
5
Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease.厄德里希-切斯特病诊断与临床管理的共识指南。
Blood. 2014 Jul 24;124(4):483-92. doi: 10.1182/blood-2014-03-561381. Epub 2014 May 21.
6
Erdheim-Chester disease.厄德海姆-切斯特病。
Curr Opin Rheumatol. 2012 Jan;24(1):53-9. doi: 10.1097/BOR.0b013e32834d861d.
7
Langerhans cell histiocytosis preceding the development of juvenile xanthogranuloma: a case and review of recent developments.幼年性黄色肉芽肿发生前的朗格汉斯细胞组织细胞增多症：1例病例及近期进展回顾
Pediatr Dev Pathol. 2011 Nov-Dec;14(6):480-4. doi: 10.2350/10-12-0950-CR.1. Epub 2011 Jul 27.
8
Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine/cytosine arabinoside.神经退行性中枢神经系统朗格汉斯细胞组织细胞增生症伴发脑积水，采用长春新碱/阿糖胞苷治疗。
Pediatr Blood Cancer. 2010 Mar;54(3):416-23. doi: 10.1002/pbc.22326.
9
Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis.18F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）与传统X线摄影及骨扫描在朗格汉斯细胞组织细胞增多症管理中的比较
Pediatr Blood Cancer. 2009 Jan;52(1):97-101. doi: 10.1002/pbc.21782.
10
Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders.朗格汉斯细胞组织细胞增多症和非朗格汉斯细胞组织细胞增生性疾病中Langerin的免疫组化表达
Am J Surg Pathol. 2008 Apr;32(4):615-9. doi: 10.1097/PAS.0b013e31815b212b.