Ranganathan Sarangarajan
Department of Pathology, Children׳s Hospital of Pittsburgh of UPMC, 4401 Penn Ave (Suite B260), Pittsburgh, Pennsylvania.
Semin Diagn Pathol. 2016 Nov;33(6):396-409. doi: 10.1053/j.semdp.2016.08.009. Epub 2016 Sep 1.
The study of Histiocytic lesions has been a passion of Pepper Dehner over the years. He has contributed several case series and reviews on various categories of these diseases for over 4 decades, with his earliest articles in the 1970s. He has written on all aspects of the disease including seminal articles on Langerhans cell histiocytosis (LCH) and their prognostic features, his experiences with regressing atypical histiocytosis, his encounters with malignant histiocytosis, and classic articles on juvenile xanthogranuloma. His contributions in the form of chapters in his 2 editions of the unique Pediatric Pathology textbook are no less important than his many articles. His experience with these lesions is highlighted in the 2 editions of the book, and the author and the audience is left wishing for more in a more current version. This article is more of a journey from descriptions and understanding of these various histiocytic syndromes to the current understanding and classifications with molecular inputs and recent advances. This article is dedicated to a master Clinician, Pathologist, and mentor whose contributions to the field of Pediatric Pathology makes him deserve beyond all doubt the title of "Father of Modern Pediatric Pathology."
多年来，对组织细胞病变的研究一直是佩珀·德内尔的热爱所在。在过去40多年里，他发表了多个关于这些疾病不同类别的病例系列和综述，其最早的文章发表于20世纪70年代。他撰写了关于该疾病各个方面的内容，包括关于朗格汉斯细胞组织细胞增多症（LCH）及其预后特征的开创性文章、他对退行性非典型组织细胞增多症的经验、他对恶性组织细胞增多症的接触，以及关于幼年黄色肉芽肿的经典文章。他在两版独特的《儿科病理学》教科书中所撰写的章节，其重要性不亚于他的众多文章。他对这些病变的经验在该书的两版中都有突出体现，读者和作者都期待能有更新版本的更多内容。本文更像是一段从对这些各种组织细胞综合征的描述和理解，到结合分子研究成果和最新进展的当前理解与分类的历程。本文献给一位杰出的临床医生、病理学家和导师，他对儿科病理学领域的贡献无疑使他当之无愧地获得“现代儿科病理学之父”的称号。
