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大剂量口服左甲状腺素片分次治疗作为黏液性水肿昏迷的一种成功治疗选择。

Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma.

作者信息

Charoensri Suranut, Sriphrapradang Chutintorn, Nimitphong Hataikarn

机构信息

Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand.

Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand.

出版信息

Clin Case Rep. 2017 Sep 8;5(10):1706-1711. doi: 10.1002/ccr3.1131. eCollection 2017 Oct.

DOI:10.1002/ccr3.1131
PMID:29026577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628197/
Abstract

High-dose intravenous thyroxine (T4) is the preferable treatment for myxedema coma. We describe the clinical course of a 69-year-old man who presented with myxedema coma and received oral levothyroxine (LT4) therapy (1 mg) in a split dose. This suggests split high-dose oral LT4 as a therapeutic option in myxedema coma.

摘要

大剂量静脉注射甲状腺素（T4）是黏液性水肿昏迷的首选治疗方法。我们描述了一名69岁男性黏液性水肿昏迷患者的临床病程，该患者接受了分次口服左甲状腺素（LT4）治疗（1毫克）。这表明分次大剂量口服LT4可作为黏液性水肿昏迷的一种治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b1/5628197/2ace887dd457/CCR3-5-1706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b1/5628197/2ace887dd457/CCR3-5-1706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b1/5628197/2ace887dd457/CCR3-5-1706-g001.jpg

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本文引用的文献

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Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan.黏液性水肿昏迷的临床特征与结局：日本全国住院患者数据库分析
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内分泌自身免疫性疾病是针对过度分泌突变体的免疫监视脆弱性。
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Crit Care. 2008;12(1):R1. doi: 10.1186/cc6211. Epub 2008 Jan 3.
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Myxedema coma.黏液性水肿昏迷
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Factors associated with mortality of patients with myxoedema coma: prospective study in 11 cases treated in a single institution.黏液性水肿昏迷患者死亡率的相关因素：对一家机构治疗的11例患者的前瞻性研究。
J Endocrinol. 2004 Feb;180(2):347-50. doi: 10.1677/joe.0.1800347.
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TREATMENT OF MYXEDEMA COMA WITH INTRAVENOUS THYROXINE.静脉注射甲状腺素治疗黏液性水肿昏迷
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