Carson Tyler, Miulli Dan
Department of Neurosurgery, Riverside University Health Systems Medical Center, Moreno Valley, California, USA.
Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, California, USA.
Surg Neurol Int. 2017 Sep 26;8:230. doi: 10.4103/sni.sni_291_16. eCollection 2017.
Intracranial abscess remains a potentially deadly condition despite development of newer antibiotics and improved surgical methods. Many studies have evaluated the surgical indications for abscess drainage, and it has been generally accepted that intracranial abscesses greater than 2.5 cm may best be treated with surgical intervention followed by antibiotic therapy. More recently, studies have shown good results with stereotactic aspiration of abscesses to 1 cm in size. Furthermore, a recent case series in 2014 of 103 cases of bedside twist drill aspiration of cerebral abscess >2.5 cm showed a good recovery in 83.4% of cases.
This case series examines the benefits of bedside twist drill aspiration of peripherally located brain abscess less than 2.5 cm in size. In our series, all patients were placed on broad-spectrum antibiotics and had negative blood and cerebrospinal fluid cultures. Our bedside biopsy resulted in de-escalation of antibiotics in 2 of the 3 patients and decreased hospital length of stay.
In patients with peripherally located brain abscesses less than 2.5 cm in size, bedside twist drill drainage may be a safe and reasonable approach. Positive identification of infective pathogen allows for a decreased hospital length of stay and de-escalation of antibiotics regiment resulting in significant reduction of hospital costs and resources in 2 of the 3 patients treated. This is of benefit to the patient as well as the health system.
尽管有了更新的抗生素和改进的手术方法,但颅内脓肿仍然是一种潜在的致命疾病。许多研究评估了脓肿引流的手术指征,一般认为直径大于2.5厘米的颅内脓肿最好采用手术干预并辅以抗生素治疗。最近,研究表明对直径达1厘米的脓肿进行立体定向抽吸取得了良好效果。此外,2014年的一项包含103例直径大于2.5厘米脑脓肿床边锥颅抽吸术的病例系列研究显示,83.4%的病例恢复良好。
本病例系列研究了对直径小于2.5厘米的周边型脑脓肿进行床边锥颅抽吸术的益处。在我们的系列研究中,所有患者均接受了广谱抗生素治疗,血液和脑脊液培养结果均为阴性。我们的床边活检使3例患者中的2例抗生素降级使用,并缩短了住院时间。
对于直径小于2.5厘米的周边型脑脓肿患者,床边锥颅引流可能是一种安全合理的方法。明确感染病原体可缩短住院时间并使抗生素治疗方案降级,从而使3例接受治疗的患者中的2例显著降低了医院成本和资源消耗。这对患者和卫生系统都有益处。