2型糖尿病与血小板指标之间的关系。
The Relationship between Type 2 Diabetes and Platelet Indicators.
作者信息
Chen Xiangyu, Fang Le, Lin Hongbo, Shen Peng, Zhang Tao, Li Hui, Li Xiaoyong, Yu Min, Xu Chunxiao, Zhang Jie, Lu Feng, DU Xiaofu, Hu Ruying, Zhong Jieming
机构信息
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, P.R. China.
Yinzhou District Center for Disease Control and Prevention, Ningbo, P.R. China.
出版信息
Iran J Public Health. 2017 Sep;46(9):1211-1216.
BACKGROUND
Currently, the studies on the relationship between type 2 diabetes and platelets indicators were carried out on a selective small sample population generally. Large sample studies in this area are rare, especially in Chinese population. In this study, we aimed to investigate the relationship between type 2 diabetes and the mean platelet volume (MPV), platelet count (PLT) and platelet distribution width (PDW).
METHODS
This is a cross-sectional analysis of the routine health examination data from 20128 participants with complete baseline data in Yinzhou District 2013. The detection of indicators in this study was completed by automatic hematology analyzer.
RESULTS
The PDW and PLT were not significantly different between diabetic group and non-diabetic group, (16.00% vs. 16.00%, =0.88, and 19410/L vs. 19610/L, =0.05 respectively). The MPV was significantly higher in diabetic group (9.3fl vs. 9.2fl, <0.05). MPV was an independent risk factor of diabetes mellitus (Unadjusted OR=1.07 (95% CI: 1.03, 1.11), Adjusted for age, sex OR=1.07 (95% CI: 1.02, 1.12)). The adjusted odds ratio of diabetes rose with increasing MPV levels and were most pronounced in subjects with MPV levels exceeding the 90th percentile (MPV ≥10.70 fl, Crude or=1.23 adjusted or=1.19).
CONCLUSION
There was no relationship between the presence of diabetes with PDW and PLT. The MPV was independently associated with the presence of diabetes.
背景
目前，关于2型糖尿病与血小板指标之间关系的研究一般是在选择性小样本群体中开展的。该领域的大样本研究较少，尤其是在中国人群中。在本研究中，我们旨在探讨2型糖尿病与平均血小板体积（MPV）、血小板计数（PLT）和血小板分布宽度（PDW）之间的关系。
方法
这是一项对2013年鄞州区20128名具有完整基线数据的参与者的常规健康检查数据进行的横断面分析。本研究中的指标检测通过自动血液分析仪完成。
结果
糖尿病组与非糖尿病组的PDW和PLT无显著差异（分别为16.00%对16.00%，P = 0.88；以及194×10⁹/L对196×10⁹/L，P = 0.05）。糖尿病组的MPV显著更高（9.3fl对9.2fl，P < 0.05）。MPV是糖尿病的独立危险因素（未调整的OR = 1.07（95%CI：1.03，1.11），调整年龄、性别后OR = 1.07（95%CI：1.02，1.12））。糖尿病的调整后比值比随着MPV水平的升高而增加，在MPV水平超过第90百分位数的受试者中最为明显（MPV≥10.70fl，粗OR = 1.23，调整后OR = 1.19）。
结论
糖尿病的存在与PDW和PLT之间无关联。MPV与糖尿病的存在独立相关。
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