Tetikoğlu Mehmet, Aktas Serdar, Sagdık Hacı Murat, Tasdemir Yigitoglu Sıla, Özcura Fatih
a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
Semin Ophthalmol. 2017;32(5):651-654. doi: 10.3109/08820538.2016.1157612. Epub 2016 Jul 1.
To evaluate the effect of the platelet indices on the stage of diabetic retinopathy (DR) and diabetic macular edema (DME).
In this retrospective study, the mean platelet valume (MPV), Plateletcrit (PCT), platelet (PLT), and platelet distribution width (PDW) of 199 diabetic patients and 76 healthy subjects were enrolled. The participants were divided into four groups. The first group was healthy control; the second group consisted of diabetic patients without DR; the third group was nonproliferative DR (NPDR); and the fourth group was proliferative DR (PDR).
Significant differences were found only in MPV and PCT values between patients with diabetes and healthy participants (8.6±0.96 fL vs 8.32±0.9 fL, P=0.011, 0.216± 0.58 vs 0.202±0.52, P=0.038). Comparing the groups, a statistically significant difference in MPV values was found between groups 4 and 1 (8.91±.7 fL vs 8.32±0.9 fL P=0.001) and between groups 4 and 3 (8.91±.7 fL vs 8.42±0.9 fL P=0.014). The MPV values of patients with DME were significantly higher than those of diabetic patients without DME (8.87±0.80 fL vs 8.45±0.97 fL).
High MPV values may be an important risk factor for the development of PDR and DME in patients with diabetic retinopathy.
评估血小板指标对糖尿病视网膜病变（DR）和糖尿病性黄斑水肿（DME）分期的影响。
在这项回顾性研究中，纳入了199例糖尿病患者和76例健康受试者的平均血小板体积（MPV）、血小板压积（PCT）、血小板（PLT）和血小板分布宽度（PDW）。参与者被分为四组。第一组为健康对照组；第二组由无DR的糖尿病患者组成；第三组为非增殖性DR（NPDR）；第四组为增殖性DR（PDR）。
仅在糖尿病患者和健康参与者之间的MPV和PCT值存在显著差异（8.6±0.96 fL对8.32±0.9 fL，P = 0.011；0.216±0.58对0.202±0.52，P = 0.038）。比较各组，第4组与第1组（8.91±0.7 fL对8.32±0.9 fL，P = 0.001）以及第4组与第3组（8.91±0.7 fL对8.42±0.9 fL，P = 0.014）之间的MPV值存在统计学显著差异。DME患者的MPV值显著高于无DME的糖尿病患者（8.87±0.80 fL对8.45±0.97 fL）。
高MPV值可能是糖尿病视网膜病变患者发生PDR和DME的重要危险因素。
