Zhou Yongxia, Bai Bing
Department of Radiology/Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY.
Department of Radiology, University of Southern California, Los Angeles, CA.
Jacobs J Med Diagn Med Imaging. 2017 Nov;2(1). Epub 2017 Aug 8.
Specific objective of this project is to quantify the neuropathological tau depositions in brain regions and to investigate primary age-related tau pathology and associations with amyloid and glucose-metabolism, neurocognitive tests and MRI metrics. Preliminary results demonstrated higher temporal deposition especially in the hippocampus and the inferior temporal regions compared to mean cortical deposition. Quantitative Braak stage-based regional analyses found highest tau deposition in the Braak stage II in the preclinical samples. There was significant age related higher tau deposition in temporal cortex, while non-significant correlation in mean cortical region. Significant correlations were found between tau deposition and memory as well as executive function scores, especially from middle and inferior temporal cortex; and significant correlations between tau and MRI metrics including diffusion, perfusion, functional and structural connectivities. Our results confirm current notion of this new tau tracer for reliably and consistently labeling and quantifying human taupathy in early dementia.
本项目的具体目标是量化脑区的神经病理学tau沉积，并研究原发性年龄相关性tau病变以及与淀粉样蛋白、葡萄糖代谢、神经认知测试和MRI指标的关联。初步结果表明，与平均皮质沉积相比，颞叶尤其是海马体和颞下回区域的沉积更高。基于Braak分期的定量区域分析发现，临床前样本中Braak II期的tau沉积最高。颞叶皮质存在与年龄相关的显著更高的tau沉积，而平均皮质区域的相关性不显著。tau沉积与记忆以及执行功能评分之间存在显著相关性，尤其是在颞中回和颞下回皮质；tau与包括扩散、灌注、功能和结构连接性在内的MRI指标之间也存在显著相关性。我们的结果证实了这种新型tau示踪剂目前的观点，即其能够可靠且一致地标记和量化早期痴呆中的人类tau病变。
