Murakami Yuki, Saito Hiroaki, Kono Yusuke, Shishido Yuji, Kuroda Hirohiko, Matsunaga Tomoyuki, Fukumoto Yoji, Osaki Tomohiro, Ashida Keigo, Fujiwara Yoshiyuki
Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
Surg Today. 2018 Apr;48(4):395-403. doi: 10.1007/s00595-017-1599-2. Epub 2017 Oct 12.
The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients.
The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC.
Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNI), preoperative PNI of < 52 (pre-PNI), postoperative PNI of ≥ 49 (post-PNI), and postoperative PNI of < 49 (pre-PNI). Both pre- and postoperative PNI were significantly associated with GC prognosis. Patients were then divided as follows: group A, patients with pre-PNI and post-PNI; group B, patients with either pre-PNI and post-PNI or pre-PNI and post-PNI; and group C, patients with pre-PNI and post-PNI. The 5-year survival rates were 100.0, 83.0, and 67.1% for groups A, B, and C, respectively. Multivariate analysis indicated that the combination of pre- and postoperative PNI was an independent prognostic indicator.
Combined analysis of the pre- and postoperative PNI offers accurate information about the prognosis of patients with GC.
预后营养指数（PNI）被认为有助于预测胃癌（GC）患者的预后。本回顾性研究调查了术前和术后PNI与GC患者预后之间的关系。
本研究的对象为254例经组织病理学诊断为GC并接受根治性手术的患者。
根据患者术前和术后的PNI进行如下分组：术前PNI≥52（术前PNI高）、术前PNI＜52（术前PNI低）、术后PNI≥49（术后PNI高）和术后PNI＜49（术前PNI低）。术前和术后PNI均与GC预后显著相关。然后将患者分为以下几组：A组，术前PNI高且术后PNI高的患者；B组，术前PNI高且术后PNI低或术前PNI低且术后PNI高的患者；C组，术前PNI低且术后PNI低的患者。A、B和C组的5年生存率分别为100.0%、83.0%和67.1%。多变量分析表明，术前和术后PNI的组合是一个独立的预后指标。
术前和术后PNI的联合分析可为GC患者的预后提供准确信息。
