Yang Bo, Liu Zhirui, Wang Qian, Xia Peiyuan
Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4118. Epub 2017 Nov 10.
During the course of decoction, the components of herbal formula interact with each other, such that chemical extraction characteristics are altered. The crude drugs, Lilium brownii (Baihe) and Rhizoma Anemarrhenae (Zhimu), are the herbal constituents of Baihe Zhimu decoction, a traditional herbal formula. To investigate the chemical interaction between Baihe and Zhimu when decocting together, eight marker components in Baihe Zhimu decoction were simultaneously characterized and quantified in one run by a hybrid triple quadrupole linear ion trap mass spectrometer in the multiple reactions monitoring-information dependent acquisition-enhanced product ion mode. The results showed that Zhimu significantly suppressed the extraction of phenolic glycosides (the components from Baihe) when co-decocting, and Baihe clearly suppressed the extraction of xanthones and steroidal saponins (the components from Zhimu). Overall, the presently developed method would be a preferred candidate for the investigation of the chemical interaction between herbal medicines.
在煎煮过程中，中药配方的成分相互作用，从而改变化学提取特性。中药百合（Baihe）和知母（Zhimu）是传统中药方剂百合知母汤的草药成分。为了研究百合和知母一起煎煮时的化学相互作用，采用混合三重四极杆线性离子阱质谱仪，在多反应监测-信息依赖采集-增强产物离子模式下，一次运行同时对百合知母汤中的8种标志物成分进行表征和定量。结果表明，知母在共煎时显著抑制了酚苷（百合中的成分）的提取，而百合明显抑制了呫吨酮和甾体皂苷（知母中的成分）的提取。总体而言，目前开发的方法将是研究草药之间化学相互作用的首选方法。
