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相似文献

1
Recombinations between IRP and cystic fibrosis.铁调节蛋白（IRP）与囊性纤维化之间的重组
Am J Hum Genet. 1988 Oct;43(4):471-5.
2
Isolation of a new DNA marker in linkage disequilibrium with cystic fibrosis, situated between J3.11 (D7S8) and IRP.分离出一种与囊性纤维化处于连锁不平衡状态的新DNA标记物，位于J3.11（D7S8）和IRP之间。
Am J Hum Genet. 1989 May;44(5):704-10.
3
Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.囊性纤维化与两个紧密连锁的DNA标记的连锁关系：一项合作研究的联合报告
Am J Hum Genet. 1986 Dec;39(6):681-93.
4
Isolation of additional polymorphic clones from the cystic fibrosis region, using chromosome jumping from D7S8.利用从D7S8进行染色体跳跃的方法，从囊性纤维化区域分离出更多的多态性克隆。
Am J Hum Genet. 1989 May;44(5):695-703.
5
Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene.
Development. 1989 Nov;107(3):643-50. doi: 10.1242/dev.107.3.643.
6
Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22 and XV-2c/CS.7.两个德国囊性纤维化家族中的交叉情况确定了MET、7C22和XV - 2c/CS.7的探针顺序。
Hum Genet. 1987 Oct;77(2):197-9. doi: 10.1007/BF00272392.
7
Linkage of cystic fibrosis locus and polymorphic DNA markers in 14 families.14个家族中囊性纤维化位点与多态性DNA标记的连锁关系。
Am J Hum Genet. 1986 Dec;39(6):707-12.
8
Linkage of DNA markers to cystic fibrosis in 26 families.26个家族中DNA标记与囊性纤维化的连锁关系。
Am J Hum Genet. 1986 Dec;39(6):729-34.
9
Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.囊性纤维化基因区域7号染色体的精细连锁图谱。
Am J Hum Genet. 1988 Jan;42(1):38-44.
10
Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8.D7S8周围标记物的产前诊断及与囊性纤维化的连锁不平衡
Hum Genet. 1990 Aug;85(3):275-8. doi: 10.1007/BF00206745.

引用本文的文献

1
Linkage disequilibrium, cystic fibrosis, and genetic counseling.连锁不平衡、囊性纤维化与遗传咨询。
Am J Hum Genet. 1989 Mar;44(3):319-26.
2
Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.通过紧密连锁的DNA标记追踪囊性纤维化中的突变。
Am J Hum Genet. 1989 Mar;44(3):303-6.
3
A 12 megabase restriction map at the cystic fibrosis locus.囊性纤维化基因座处的一个12兆碱基限制酶切图谱。
Nucleic Acids Res. 1989 Jan 11;17(1):271-84. doi: 10.1093/nar/17.1.271.
4
Linkage disequilibrium for DNA haplotypes near the cystic fibrosis locus in two south European populations.两个南欧人群中囊性纤维化基因座附近DNA单倍型的连锁不平衡
Hum Genet. 1989 Sep;83(2):175-8. doi: 10.1007/BF00286713.
5
Physical localization of two DNA markers closely linked to the cystic fibrosis locus by pulsed-field gel electrophoresis.通过脉冲场凝胶电泳对与囊性纤维化基因座紧密连锁的两个DNA标记进行物理定位。
Am J Hum Genet. 1989 Dec;45(6):932-41.
6
DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.DNA标记单倍型与囊性纤维化患者胰腺功能的关联
Am J Hum Genet. 1989 Jun;44(6):827-34.
7
Isolation of a new DNA marker in linkage disequilibrium with cystic fibrosis, situated between J3.11 (D7S8) and IRP.分离出一种与囊性纤维化处于连锁不平衡状态的新DNA标记物，位于J3.11（D7S8）和IRP之间。
Am J Hum Genet. 1989 May;44(5):704-10.
8
Cystic fibrosis mutations in the Hutterite Brethren.哈特泰特人中的囊性纤维化突变
Am J Hum Genet. 1990 May;46(5):983-7.
9
Crossover in a Spanish cystic fibrosis family.一个西班牙囊性纤维化家族中的交叉遗传现象。
Hum Genet. 1990 Nov;86(1):102. doi: 10.1007/BF00205186.
10
Frequency of the F508 deletion in cystic fibrosis patients from the European part of the USSR.
Hum Genet. 1991 May;87(1):61-4. doi: 10.1007/BF01213094.

本文引用的文献

1
Microvillar peptidase activity in amniotic fluid: possible use in the prenatal diagnosis of cystic fibrosis.
Lancet. 1983 Feb 12;1(8320):329-31. doi: 10.1016/s0140-6736(83)91630-6.
2
Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.从七号染色体上分离出另一个与囊性纤维化紧密连锁的匿名信息性DNA序列。
Nucleic Acids Res. 1986 Mar 11;14(5):1951-6. doi: 10.1093/nar/14.5.1951.
3
A closely linked genetic marker for cystic fibrosis.一种与囊性纤维化紧密连锁的遗传标记。
Nature. 1985;318(6044):382-4. doi: 10.1038/318382a0.
4
Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis.对200例生育囊性纤维化风险为四分之一的孕妇进行产前诊断。
Hum Genet. 1986 Nov;74(3):288-97. doi: 10.1007/BF00282551.
5
Experience with new DNA markers for the diagnosis of cystic fibrosis.
N Engl J Med. 1988 Jan 7;318(1):50-1. doi: 10.1056/NEJM198801073180114.
6
Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.囊性纤维化与两个紧密连锁的DNA标记的连锁关系：一项合作研究的联合报告
Am J Hum Genet. 1986 Dec;39(6):681-93.
7
Localization of cystic fibrosis locus to human chromosome 7cen-q22.囊性纤维化基因座定位于人类染色体7cen-q22。
Nature. 1985;318(6044):384-5. doi: 10.1038/318384a0.
8
A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.
Nature. 1985;318(6044):380-2. doi: 10.1038/318380a0.
9
Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny.
Clin Genet. 1985 Oct;28(4):265-71. doi: 10.1111/j.1399-0004.1985.tb00400.x.
10
An estimate of unique DNA sequence heterozygosity in the human genome.人类基因组中独特DNA序列杂合性的估计。
Hum Genet. 1985;69(3):201-5. doi: 10.1007/BF00293024.

铁调节蛋白（IRP）与囊性纤维化之间的重组

Recombinations between IRP and cystic fibrosis.

作者信息

Farrall M, Wainwright B J, Feldman G L, Beaudet A, Sretenovic Z, Halley D, Simon M, Dickerman L, Devoto M, Romeo G

机构信息

Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, University of London, United Kingdom.

出版信息

Am J Hum Genet. 1988 Oct;43(4):471-5.

PMID:2902786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1715502/
Abstract

A candidate gene for cystic fibrosis was recently isolated by selective cloning of HpaII-tiny-fragment islands; it maps considerably closer to CF than does MET or D7S8 (pJ3.11), and DNA polymorphisms from this region are in marked disequilibrium with CF. cDNA cloning has shown that this protein has a growth factor-like structure and shows homology to the murine and human proto-oncogene int-1; it is designated IRP (int-1-related protein). DNA sequences from the IRP locus that recognize RFLPs are proving to be highly informative for prenatal diagnosis. We report five crossovers that have been identified which occur either within the IRP locus or between IRP and CF; these recombinants demonstrate that CF maps between the DNA markers D7S8 and KM.19.

摘要

最近通过对HpaII微小片段岛的选择性克隆分离出了一个囊性纤维化候选基因；它的定位比MET或D7S8（pJ3.11）更接近CF，并且该区域的DNA多态性与CF存在明显的不平衡。cDNA克隆表明，这种蛋白质具有生长因子样结构，与小鼠和人类原癌基因int-1具有同源性；它被命名为IRP（int-1相关蛋白）。来自IRP基因座的识别RFLP的DNA序列被证明对产前诊断具有很高的信息量。我们报告了已鉴定出的五个交换事件，它们发生在IRP基因座内或IRP与CF之间；这些重组体表明CF位于DNA标记D7S8和KM.19之间。