Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.
作者信息
Tsui L C
机构信息
Department of Genetics, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada.
出版信息
Am J Hum Genet. 1989 Mar;44(3):303-6.
Abstract
摘要
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Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia.β-珠蛋白基因区域DNA序列的多态性。在撒丁岛β0地中海贫血产前诊断中的应用。
N Engl J Med. 1980 Jan 24;302(4):185-8. doi: 10.1056/NEJM198001243020401.
2
Quantification of the close association between DNA haplotypes and specific beta-thalassaemia mutations in Mediterraneans.地中海人群中DNA单倍型与特定β地中海贫血突变之间紧密关联的定量分析。
Nature. 1984;310(5973):152-4. doi: 10.1038/310152a0.
3
Genetic studies on cystic fibrosis in Hawaii.夏威夷囊性纤维化的遗传学研究。
Am J Hum Genet. 1968 Mar;20(2):157-69.
4
Report of the committee on the genetic constitution of chromosomes 7, 8 and 9.
Cytogenet Cell Genet. 1987;46(1-4):170-87. doi: 10.1159/000132476.
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Studies of cystic fibrosis in Hutterite families by using linked DNA probes.运用连锁DNA探针研究哈特派家族中的囊性纤维化。
Am J Hum Genet. 1987 Dec;41(6):1145-51.
6
Genetic analysis of cystic fibrosis using linked DNA markers.使用连锁DNA标记对囊性纤维化进行基因分析。
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7
Experience with new DNA markers for the diagnosis of cystic fibrosis.
N Engl J Med. 1988 Jan 7;318(1):50-1. doi: 10.1056/NEJM198801073180114.
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A test of the heterozygote-advantage hypothesis in cystic fibrosis carriers.囊性纤维化携带者杂合子优势假说的一项测试。
Am J Hum Genet. 1988 Jun;42(6):808-15.
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No evidence for genetic heterogeneity in cystic fibrosis.囊性纤维化不存在基因异质性的证据。
Am J Hum Genet. 1988 Jan;42(1):184.
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Hypothesis: a selective advantage for cystic fibrosis heterozygotes.假设：囊性纤维化杂合子具有选择优势。
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