胰岛素对麻醉的泌乳大鼠乳腺葡萄糖代谢的调节。果糖2,6 -二磷酸对磷酸果糖激酶-1的刺激作用以及乙酰辅酶A羧化酶的激活。
Regulation by insulin of glucose metabolism in mammary gland of anaesthetized lactating rats. Stimulation of phosphofructokinase-1 by fructose 2,6-bisphosphate and activation of acetyl-CoA carboxylase.
作者信息
Burnol A F, Ebner S, Ferré P, Girard J
机构信息
Centre de recherches sur la Nutrition du CNRS, Meudon-Bellevue, France.
出版信息
Biochem J. 1988 Aug 15;254(1):11-4. doi: 10.1042/bj2540011.
Abstract
The effect of insulin on glucose metabolism in mammary gland was studied by the euglycaemic/hyperinsulinaemic-clamp technique. Measurement of metabolite concentrations and enzyme activities in the mammary gland suggests two sites of action of insulin: phosphofructokinase-1 and acetyl-coA carboxylase. The increase in phosphofructokinase-1 activity could be linked to the 2-fold increase in fructose 2,6-bisphosphate concentration, since no change in maximal activity and in sensitivity of the enzyme toward fructose 6-phosphate was detected in vitro.
摘要
采用正常血糖/高胰岛素钳夹技术研究了胰岛素对乳腺葡萄糖代谢的影响。对乳腺中代谢物浓度和酶活性的测定表明胰岛素有两个作用位点：磷酸果糖激酶-1和乙酰辅酶A羧化酶。磷酸果糖激酶-1活性的增加可能与果糖2,6-二磷酸浓度增加2倍有关，因为在体外未检测到该酶的最大活性和对6-磷酸果糖敏感性的变化。
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