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相似文献

1
Regulation by insulin of glucose metabolism in mammary gland of anaesthetized lactating rats. Stimulation of phosphofructokinase-1 by fructose 2,6-bisphosphate and activation of acetyl-CoA carboxylase.胰岛素对麻醉的泌乳大鼠乳腺葡萄糖代谢的调节。果糖2,6 -二磷酸对磷酸果糖激酶-1的刺激作用以及乙酰辅酶A羧化酶的激活。
Biochem J. 1988 Aug 15;254(1):11-4. doi: 10.1042/bj2540011.
2
Regulation of fatty acid synthesis in lactating rat mammary gland in the fed to starved transition: asynchronous control of pyruvate dehydrogenase, phosphofructokinase and acetyl-CoA carboxylase.从进食到饥饿转变过程中泌乳大鼠乳腺脂肪酸合成的调节：丙酮酸脱氢酶、磷酸果糖激酶和乙酰辅酶A羧化酶的异步调控
Comp Biochem Physiol B. 1991;100(3):527-34. doi: 10.1016/0305-0491(91)90215-y.
3
Insulin activation of lipogenesis in isolated mammary acini from lactating rats fed on a high-fat diet. Evidence that acetyl-CoA carboxylase is a site of action.胰岛素对高脂饮食喂养的泌乳大鼠分离乳腺腺泡中脂肪生成的激活作用。乙酰辅酶A羧化酶是作用位点的证据。
Biochem J. 1987 Mar 15;242(3):905-11. doi: 10.1042/bj2420905.
4
Fructose 2,6-bisphosphate, sugar phosphates and adenine nucleotides in the regulation of glucose metabolism in the lactating rat mammary gland.果糖2,6-二磷酸、磷酸糖和腺嘌呤核苷酸在泌乳大鼠乳腺葡萄糖代谢调节中的作用
FEBS Lett. 1984 Apr 9;169(1):12-6. doi: 10.1016/0014-5793(84)80279-3.
5
The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats.乙酰辅酶A羧化酶磷酸化在泌乳大鼠饥饿和重新喂食期间乳腺脂肪酸合成调控中的作用。
Biochem J. 1986 Jul 1;237(1):85-91. doi: 10.1042/bj2370085.
6
The role of pyruvate dehydrogenase, phosphofructo-1-kinase and acetyl-CoA carboxylase in the regulation of fatty acid synthesis in the lactating rat mammary gland during the starved to re-fed transition.饥饿至重新进食过渡期间，丙酮酸脱氢酶、磷酸果糖-1-激酶和乙酰辅酶A羧化酶在泌乳大鼠乳腺脂肪酸合成调节中的作用。
Biochim Biophys Acta. 1997 Oct 20;1336(3):474-84. doi: 10.1016/s0304-4165(97)00061-5.
7
Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo.大鼠乳腺中乙酰辅酶A羧化酶的调节。饥饿以及胰岛素和催乳素缺乏对体内活性形式酶的比例的影响。
Biochem J. 1982 Apr 15;204(1):273-80. doi: 10.1042/bj2040273.
8
The regulation of lipogenesis in vivo in the lactating mammary gland of the rat during the starved-refed transition. Studies wtih acarbose, a glucosidase inhibitor.饥饿-再喂养过渡期大鼠泌乳乳腺体内脂肪生成的调节。使用阿卡波糖（一种葡萄糖苷酶抑制剂）的研究。
Biochem J. 1987 Feb 15;242(1):235-43. doi: 10.1042/bj2420235.
9
An 'in situ' perfusion system suitable for investigating mammary-tissue metabolism in the lactating rat. Hormonal regulation of acetyl-CoA carboxylase.一种适用于研究泌乳大鼠乳腺组织代谢的“原位”灌注系统。乙酰辅酶A羧化酶的激素调节。
Biochem J. 1988 Feb 1;249(3):771-7. doi: 10.1042/bj2490771.
10
Growth-hormone-prolactin interactions in the regulation of mammary and adipose-tissue acetyl-CoA carboxylase activity and gene expression in lactating rats.生长激素与催乳素在泌乳大鼠乳腺和脂肪组织乙酰辅酶A羧化酶活性及基因表达调控中的相互作用
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):469-75. doi: 10.1042/bj2850469.

引用本文的文献

1
A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.乳糖合成调控的外在和内在因素的比较评价
J Mammary Gland Biol Neoplasia. 2021 Jun;26(2):197-215. doi: 10.1007/s10911-021-09491-6. Epub 2021 Jun 14.
2
The insulin receptor plays an important role in secretory differentiation in the mammary gland.胰岛素受体在乳腺的分泌分化中发挥重要作用。
Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1103-14. doi: 10.1152/ajpendo.00337.2013. Epub 2013 Aug 27.
3
Insulin action on the lactating-rat mammary gland: intracellular glucose and its phosphorylation.胰岛素对泌乳大鼠乳腺的作用：细胞内葡萄糖及其磷酸化
Biochem J. 1989 Feb 1;257(3):933-4. doi: 10.1042/bj2570933.
4
Glucose transporter expression in rat mammary gland.大鼠乳腺中葡萄糖转运蛋白的表达。
Biochem J. 1990 Aug 15;270(1):277-9. doi: 10.1042/bj2700277.
5
Chain-length dependency of interactions of medium-chain fatty acids with glucose metabolism in acini isolated from lactating rat mammary glands. A putative feed-back to control milk lipid synthesis from glucose.从泌乳大鼠乳腺分离的腺泡中，中链脂肪酸与葡萄糖代谢相互作用的链长依赖性。一种从葡萄糖控制乳脂合成的假定反馈。
Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):273-8. doi: 10.1042/bj2810273.

本文引用的文献

1
Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding.短期饥饿和再喂养对泌乳大鼠乳腺血流及葡萄糖代谢的影响
Biosci Rep. 1984 May;4(5):421-6. doi: 10.1007/BF01122507.
2
Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.胰岛素和胰高血糖素对泌乳大鼠乳腺脂肪生成的体内调节。胰岛素在转变为饥饿状态过程中的作用及作用位点。
Biochem J. 1984 Oct 15;223(2):345-51. doi: 10.1042/bj2230345.
3
Monosaccharide transport in the mammary gland of the intact lactating rat.完整泌乳大鼠乳腺中的单糖转运
Biochem J. 1984 Feb 15;218(1):213-9. doi: 10.1042/bj2180213.
4
Glucose metabolism during lactation in the rat: quantitative and regulatory aspects.大鼠哺乳期的葡萄糖代谢：定量与调节方面
Am J Physiol. 1983 Oct;245(4):E351-8. doi: 10.1152/ajpendo.1983.245.4.E351.
5
A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate.马铃薯块茎中焦磷酸：果糖-6-磷酸磷酸转移酶的动力学研究。用于果糖2,6-二磷酸的微量测定。
Eur J Biochem. 1982 Dec;129(1):191-5. doi: 10.1111/j.1432-1033.1982.tb07039.x.
6
Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo.大鼠乳腺中乙酰辅酶A羧化酶的调节。饥饿以及胰岛素和催乳素缺乏对体内活性形式酶的比例的影响。
Biochem J. 1982 Apr 15;204(1):273-80. doi: 10.1042/bj2040273.
7
Effects of starvation, insulin or prolactin deficiency on the activity of acetyl-CoA carboxylase in mammary gland and liver of lactating rats.饥饿、胰岛素或催乳素缺乏对泌乳大鼠乳腺和肝脏中乙酰辅酶A羧化酶活性的影响。
FEBS Lett. 1982 Feb 22;138(2):285-8. doi: 10.1016/0014-5793(82)80462-6.
8
Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase.胰岛素与脂肪组织乙酰辅酶A羧化酶的调节
Biochem J. 1973 Mar;132(3):509-17. doi: 10.1042/bj1320509.
9
Evidence that the stimulation of lipogenesis in the mammary glands of starved lactating rats re-fed with a chow diet is dependent on continued hepatic gluconeogenesis during the absorptive period. Effects of a gluconeogenic inhibitory, mercaptopicolinic acid, in vivo.饥饿的哺乳期大鼠重新喂食普通饲料后，乳腺中脂肪生成的刺激依赖于吸收期肝脏持续的糖异生作用的证据。生糖抑制物巯基吡啶酸在体内的作用。
Biochem J. 1985 Jun 15;228(3):727-33. doi: 10.1042/bj2280727.
10
Effect of insulin on in vivo glucose utilization in individual tissues of anesthetized lactating rats.胰岛素对麻醉泌乳大鼠各组织体内葡萄糖利用的影响。
Am J Physiol. 1987 Feb;252(2 Pt 1):E183-8. doi: 10.1152/ajpendo.1987.252.2.E183.

胰岛素对麻醉的泌乳大鼠乳腺葡萄糖代谢的调节。果糖2,6 -二磷酸对磷酸果糖激酶-1的刺激作用以及乙酰辅酶A羧化酶的激活。

Regulation by insulin of glucose metabolism in mammary gland of anaesthetized lactating rats. Stimulation of phosphofructokinase-1 by fructose 2,6-bisphosphate and activation of acetyl-CoA carboxylase.

作者信息

Burnol A F, Ebner S, Ferré P, Girard J

机构信息

Centre de recherches sur la Nutrition du CNRS, Meudon-Bellevue, France.

出版信息

Biochem J. 1988 Aug 15;254(1):11-4. doi: 10.1042/bj2540011.

DOI:10.1042/bj2540011
PMID:2902845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1135031/
Abstract

The effect of insulin on glucose metabolism in mammary gland was studied by the euglycaemic/hyperinsulinaemic-clamp technique. Measurement of metabolite concentrations and enzyme activities in the mammary gland suggests two sites of action of insulin: phosphofructokinase-1 and acetyl-coA carboxylase. The increase in phosphofructokinase-1 activity could be linked to the 2-fold increase in fructose 2,6-bisphosphate concentration, since no change in maximal activity and in sensitivity of the enzyme toward fructose 6-phosphate was detected in vitro.

摘要

采用正常血糖/高胰岛素钳夹技术研究了胰岛素对乳腺葡萄糖代谢的影响。对乳腺中代谢物浓度和酶活性的测定表明胰岛素有两个作用位点：磷酸果糖激酶-1和乙酰辅酶A羧化酶。磷酸果糖激酶-1活性的增加可能与果糖2,6-二磷酸浓度增加2倍有关，因为在体外未检测到该酶的最大活性和对6-磷酸果糖敏感性的变化。