完整泌乳大鼠乳腺中的单糖转运
Monosaccharide transport in the mammary gland of the intact lactating rat.
作者信息
Threadgold L C, Kuhn N J
出版信息
Biochem J. 1984 Feb 15;218(1):213-9. doi: 10.1042/bj2180213.
Abstract
The Michaelis-Menten equation for the utilization of competing substrates was applied to the uptake of 2-deoxy[3H]glucose into the mammary gland of anaesthetized lactating rats. Intracellular water was calculated from total tissue water and sucrose space. Fed rats had a mean transport capacity of 2.2 mumol/min per g of tissue, giving an actual glucose transport in vivo of 1.1 mumol/min per g. Transport decreased by 90% on overnight starvation and returned to normal by 2 h of re-feeding. Similar changes were observed in the 1 min or 5 min transport of circulating 3-O-methylglucose. Transport of 3-O-methylglucose in starved rats was restored towards normal by insulin. In fed rats it increased between parturition and day 12 of lactation. The findings support the proposal that transport is a rate-limiting factor in the mammary utilization of carbohydrate.
摘要
用于竞争性底物利用的米氏方程被应用于麻醉的泌乳大鼠乳腺对2-脱氧[3H]葡萄糖的摄取。细胞内水由总组织水和蔗糖间隙计算得出。喂食的大鼠每克组织的平均转运能力为2.2 μmol/分钟，体内实际葡萄糖转运为每克1.1 μmol/分钟。禁食一夜后转运下降90%，重新喂食2小时后恢复正常。在循环3-O-甲基葡萄糖的1分钟或5分钟转运中也观察到类似变化。饥饿大鼠中3-O-甲基葡萄糖的转运通过胰岛素恢复正常。在喂食的大鼠中，它在分娩至泌乳第12天之间增加。这些发现支持了转运是乳腺利用碳水化合物的限速因素这一观点。
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