Couroucé A M
Institut National de Transfusion Sanguine, Paris, France.
AIDS. 1988 Aug;2(4):261-5.
A seroepidemiological surveillance study to investigate the spread of HIV-2 infection in France was organized in the last semester of 1987 on 100 114 blood donors and 10 004 selected people. Sera were simultaneously tested for antibodies to HIV-1 and to HIV-2 by enzyme-linked immunosorbent assay (ELISA) and were confirmed by specific Western blot. A spot test using synthetic peptides was also applied when a sample was reactive by ELISA HIV-1 and HIV-2 and was confirmed as HIV-1 by Western blot. A total of 30 blood donors were confirmed as HIV-1 positive (0.030%) and no sample was confirmed as HIV-2 positive. In the selected population, the prevalence of HIV-infected people was 7.1% for HIV-1 and 0.09% for HIV-2. Eight of the nine HIV-2 cases were directly or indirectly connected to West Africa. Only one HIV-2 case had no known contact with these countries; he has been transfused and is under investigation. Except for this possible HIV-2 infection in a blood recipient, no HIV-2 seropositivity was found in at-risk groups (homosexuals, drug addicts and haemophiliacs). At present, HIV-2 does not seem to be widely spread in France. Seroepidemiological surveillance will be continued.
1987年下半年，法国组织了一项血清流行病学监测研究，以调查HIV-2感染在法国的传播情况。该研究针对100114名献血者和10004名选定人群展开。通过酶联免疫吸附测定（ELISA）同时检测血清中针对HIV-1和HIV-2的抗体，并通过特异性蛋白质印迹法进行确认。当样本经ELISA检测对HIV-1和HIV-2呈反应性且经蛋白质印迹法确认为HIV-1时，还会应用合成肽斑点试验。共有30名献血者被确认为HIV-1阳性（0.030%），没有样本被确认为HIV-2阳性。在选定人群中，HIV-1感染者的患病率为7.1%，HIV-2感染者的患病率为0.09%。9例HIV-2病例中有8例与西非有直接或间接联系。只有1例HIV-2病例与这些国家无已知接触；他接受过输血，正在接受调查。除了这例受血者可能感染HIV-2外，在高危人群（同性恋者、吸毒者和血友病患者）中未发现HIV-2血清阳性。目前，HIV-2在法国似乎没有广泛传播。血清流行病学监测将继续进行。
