From the aDepartment of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; and bInstitute of Industrial Hygiene and Occupational Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Epidemiology. 2017 Oct;28 Suppl 1:S74-S81. doi: 10.1097/EDE.0000000000000715.
Studies evaluating possible associations between long-term exposure to air pollution and inflammatory and thrombotic markers are limited.
From 2009 to 2011, we monitored hematologic parameters and thrombotic markers in 402 volunteers 35-65 years of age who were recruited as the non-coronary heart disease (CHD) controls in a study of work-related factors and CHD in Taipei. We applied land-use regression models developed by the European Study of Cohorts for Air Pollution Effects to estimate the mean annual exposure of each participant to five air pollutants at their residence in Taipei, namely particulate matter (PM) of diameter <10 μm (PM10) and 2.5 μm (PM2.5), the absorbance of PM2.5 (PM2.5 abs), nitrogen dioxide (NO2), and nitrogen oxide (NOx).
The mean annual exposures were 47.82 ± 4.78 µg/m for PM10, 29.08 ± 5.10 µg/m for PM2.5, and 2.04 ± 0.37 (10 m) for PM2.5 abs. Multivariate linear regression analyses showed that the mean percentage (95% confidence interval) of blood monocyte counts increased by 9.08% (1.61%, 16.54%) per 10 µg/m increase in PM10, by 16.28% (6.66%, 25.89%) per 1.0 × 10 m increase in PM2.5 abs, by 8.28% (2.08%, 14.48%) per 20 µg/m increase in NO2, and by 2.84% (1.22%, 4.46%) per 10 µg/m increase in NOx. In addition, each 5 μg/m increase in PM2.5 was associated with 1.97% (0.02%, 3.92%) increases in fibrinogen.
Long-term exposure to traffic-related air pollution is positively associated with subclinical inflammatory and thrombotic markers in middle-aged workers in Taipei.
评估长期暴露于空气污染与炎症和血栓形成标志物之间可能存在关联的研究有限。
在 2009 年至 2011 年期间，我们监测了 402 名年龄在 35-65 岁之间的志愿者的血液学参数和血栓形成标志物，他们是台北一项与工作相关因素和冠心病研究中的非冠心病（CHD）对照组。我们应用欧洲大气污染效应队列研究开发的用地回归模型，来估计每位参与者在台北居住地每年对五种空气污染物的平均暴露量，即直径<10μm（PM10）和 2.5μm（PM2.5）的颗粒物、PM2.5 的吸光度（PM2.5abs）、二氧化氮（NO2）和氮氧化物（NOx）。
PM10 的年平均暴露量为 47.82 ± 4.78 µg/m，PM2.5 为 29.08 ± 5.10 µg/m，PM2.5abs 为 2.04 ± 0.37（10 m）。多元线性回归分析显示，PM10 每增加 10µg/m，血单核细胞计数的平均百分比（95%置信区间）增加 9.08%（1.61%，16.54%），PM2.5abs 每增加 1.0×10 m 增加 16.28%（6.66%，25.89%），NO2 每增加 20µg/m 增加 8.28%（2.08%，14.48%），NOx 每增加 10µg/m 增加 2.84%（1.22%，4.46%）。此外，PM2.5 每增加 5µg/m，纤维蛋白原增加 1.97%（0.02%，3.92%）。
长期接触交通相关空气污染与台北中年工人亚临床炎症和血栓形成标志物呈正相关。
