Su Ta-Chen, Hwang Juey-Jen, Shen Yu-Cheng, Chan Chang-Chuan
Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Environ Health Perspect. 2015 Aug;123(8):773-8. doi: 10.1289/ehp.1408553. Epub 2015 Mar 20.
Associations between long-term exposure to air pollution and carotid intima-media thickness (CIMT) have inconsistent findings.
In this study we aimed to evaluate association between 1-year average exposure to traffic-related air pollution and CIMT in middle-aged adults in Asia.
CIMT was measured in Taipei, Taiwan, between 2009 and 2011 in 689 volunteers 35-65 years of age who were recruited as the control subjects of an acute coronary heart disease cohort study. We applied land-use regression models developed by the European Study of Cohorts for Air Pollution Effects (ESCAPE) to estimate each subject's 1-year average exposure to traffic-related air pollutants with particulate matter diameters ≤ 10 μm (PM10) and ≤ 2.5 μm (PM2.5) and the absorbance levels of PM2.5 (PM2.5abs), nitrogen dioxide (NO2), and nitrogen oxides (NOx) in the urban environment.
One-year average air pollution exposures were 44.21 ± 4.19 μg/m3 for PM10, 27.34 ± 5.12 μg/m3 for PM2.5, and (1.97 ± 0.36) × 10-5/m for PM2.5abs. Multivariate regression analyses showed average percentage increases in maximum left CIMT of 4.23% (95% CI: 0.32, 8.13) per 1.0 × 10-5/m increase in PM2.5abs; 3.72% (95% CI: 0.32, 7.11) per 10-μg/m3 increase in PM10; 2.81% (95% CI: 0.32, 5.31) per 20-μg/m3 increase in NO2; and 0.74% (95% CI: 0.08, 1.41) per 10-μg/m3 increase in NOx. The associations were not evident for right CIMT, and PM2.5 mass concentration was not associated with the outcomes.
Long-term exposures to traffic-related air pollution of PM2.5abs, PM10, NO2, and NOx were positively associated with subclinical atherosclerosis in middle-aged adults.
长期暴露于空气污染与颈动脉内膜中层厚度（CIMT）之间的关联研究结果并不一致。
本研究旨在评估亚洲中年成年人中与交通相关的空气污染1年平均暴露量与CIMT之间的关联。
2009年至2011年期间，在台湾台北对689名年龄在35至65岁之间的志愿者进行了CIMT测量，这些志愿者是一项急性冠心病队列研究的对照受试者。我们应用了由欧洲空气污染影响队列研究（ESCAPE）开发的土地利用回归模型，以估计每位受试者在城市环境中与交通相关的空气污染物的1年平均暴露量，这些污染物包括直径≤10μm（PM10）和≤2.5μm（PM2.5）的颗粒物以及PM2.5的吸光度水平（PM2.5abs）、二氧化氮（NO2）和氮氧化物（NOx）。
PM10的1年平均空气污染暴露量为44.21±4.19μg/m3，PM2.5为27.34±5.12μg/m3，PM2.5abs为(1.97±0.36)×10-5/m。多变量回归分析显示，PM2.5abs每增加1.0×10-5/m，最大左CIMT平均百分比增加4.23%（95%CI：0.32，8.13）；PM10每增加10μg/m3，增加3.72%（95%CI：0.32，7.11）；NO2每增加20μg/m3，增加2.81%（95%CI：0.32，5.31）；NOx每增加10μg/m3，增加0.74%（95%CI：0.08，1.41）。右侧CIMT的关联不明显，且PM2.5质量浓度与研究结果无关。
长期暴露于与交通相关的PM2.5abs、PM10、NO2和NOx空气污染与中年成年人的亚临床动脉粥样硬化呈正相关。
