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信号转导与转录激活因子、无翅基因和核小体重塑因子38决定果蝇辐射损伤后再生的准确性。

STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila.

作者信息

Verghese Shilpi, Su Tin Tin

机构信息

Department of Molecular, Cellular and Developmental Biology, UCB, University of Colorado, Boulder, CO, United States of America.

University of Colorado Comprehensive Cancer Center, Anschutz Medical Campus, Aurora, CO, United States of America.

出版信息

PLoS Genet. 2017 Oct 13;13(10):e1007055. doi: 10.1371/journal.pgen.1007055. eCollection 2017 Oct.

DOI:10.1371/journal.pgen.1007055
PMID:29028797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5656321/
Abstract

We report here a study of regeneration in Drosophila larval wing imaginal discs after damage by ionizing radiation. We detected faithful regeneration that restored a wing disc and abnormal regeneration that produced an extra wing disc. We describe a sequence of changes in cell number, location and fate that occur to produce an ectopic disc. We identified a group of cells that not only participate in ectopic disc formation but also recruit others to do so. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth. The picture that emerges is one in which activities like STAT increase after radiation damage and fulfill essential roles in rebuilding the tissue. But such activities must be kept in check so that one and only one wing disc is regenerated.

摘要

我们在此报告一项关于果蝇幼虫翅成虫盘在受到电离辐射损伤后的再生研究。我们检测到了恢复翅成虫盘的忠实再生以及产生额外翅成虫盘的异常再生。我们描述了为产生异位盘而发生的细胞数量、位置和命运的一系列变化。我们鉴定出了一组细胞，它们不仅参与异位盘的形成，还招募其他细胞参与。STAT92E（果蝇STAT3/5）和编码核小体重塑因子复合物成员的Nurf-38在这些细胞中相互拮抗，以调节异位盘生长的频率。呈现出的情况是，像STAT这样的活性在辐射损伤后增加，并在组织重建中发挥重要作用。但必须对这些活性进行控制，以便仅再生出一个翅成虫盘。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/e2b7ad0e0c3f/pgen.1007055.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/8c12b2c70de5/pgen.1007055.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/ac6175723a3b/pgen.1007055.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/5565bca85ef3/pgen.1007055.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/9f7b8746fd39/pgen.1007055.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/e17ad27cc521/pgen.1007055.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/e2b7ad0e0c3f/pgen.1007055.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/8c12b2c70de5/pgen.1007055.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/ac6175723a3b/pgen.1007055.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/5565bca85ef3/pgen.1007055.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/9f7b8746fd39/pgen.1007055.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/e17ad27cc521/pgen.1007055.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a24/5656321/e2b7ad0e0c3f/pgen.1007055.g006.jpg

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