多巴胺拮抗剂对刺激引起的纹状体和边缘系统多巴胺释放的作用：一项体内伏安法研究。
Actions of dopamine antagonists on stimulated striatal and limbic dopamine release: an in vivo voltammetric study.
作者信息
Stamford J A, Kruk Z L, Millar J
机构信息
Department of Pharmacology, London Hospital Medical College.
出版信息
Br J Pharmacol. 1988 Jul;94(3):924-32. doi: 10.1111/j.1476-5381.1988.tb11605.x.
Abstract
- Fast cyclic voltammetry at carbon fibre microelectrodes was used to study the effects of several dopamine antagonists upon stimulated dopamine release in the rat striatum and nucleus accumbens. 2. In both nuclei, stimulated dopamine release was increased by D2-receptor-selective and mixed D1/D2-receptor antagonists. The D1-selective antagonist SCH 23390 had no effect. 3. Striatal and limbic dopamine release were elevated by cis- but not trans-flupenthixol. 4. The 'atypical' neuroleptics (clozapine and thioridazine) did not cause a selective elevation of dopamine release in the limbic terminal region, whereas the non-antipsychotic drug metoclopramide increased dopamine release more in striatum than nucleus accumbens. 5. We conclude from this study that striatal and limbic dopamine release are under the control of a stereoselective dopamine D2-autoreceptor on the nerve terminal and that atypical neuroleptics do not show a limbic-selective effect at this receptor after acute administration.
摘要
- 采用碳纤维微电极快速循环伏安法研究了几种多巴胺拮抗剂对大鼠纹状体和伏隔核中刺激诱导的多巴胺释放的影响。2. 在这两个核中，D2受体选择性拮抗剂和D1/D2受体混合拮抗剂均可增加刺激诱导的多巴胺释放。D1选择性拮抗剂SCH 23390无此作用。3. 顺式氟奋乃静可提高纹状体和边缘系统的多巴胺释放，而反式氟奋乃静则无此作用。4. “非典型”抗精神病药物（氯氮平和硫利达嗪）并未导致边缘终末区多巴胺释放选择性升高，而非抗精神病药物甲氧氯普胺在纹状体中比在伏隔核中更能增加多巴胺释放。5. 我们从这项研究得出结论，纹状体和边缘系统的多巴胺释放受神经末梢上立体选择性多巴胺D2自身受体的控制，急性给药后，非典型抗精神病药物在该受体上未表现出边缘系统选择性效应。
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