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环境与膀胱癌：通过相互作用网络进行分子分析

Environment and bladder cancer: molecular analysis by interaction networks.

作者信息

Polo Andrea, Crispo Anna, Cerino Pellegrino, Falzone Luca, Candido Saverio, Giudice Aldo, De Petro Giuseppina, Ciliberto Gennaro, Montella Maurizio, Budillon Alfredo, Costantini Susan

机构信息

Epidemiology Unit, Istituto Nazionale Tumori "Fondazione G. Pascale", IRCCS, Napoli, Italia.

Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), Napoli, Italia.

出版信息

Oncotarget. 2017 May 26;8(39):65240-65252. doi: 10.18632/oncotarget.18222. eCollection 2017 Sep 12.

DOI:10.18632/oncotarget.18222
PMID:29029427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5630327/
Abstract

Bladder cancer (BC) is the 9th most common cancer worldwide, and the 6th most common cancer in men. Its development is linked to chronic inflammation, genetic susceptibility, smoking, occupational exposures and environmental pollutants. Aim of this work was to identify a sub-network of genes/proteins modulated by environmental or arsenic exposure in BC by computational network approaches. Our studies evidenced the presence of HUB nodes both in "BC and environment" and "BC and arsenicals" networks. These HUB nodes resulted to be correlated to circadian genes and targeted by some miRNAs already reported as involved in BC, thus suggesting how they play an important role in BC development due to environmental or arsenic exposure. Through data-mining analysis related to putative effect of the identified HUB nodes on survival we identified genes/proteins and their mutations on which it will be useful to focus further experimental studies related to the evaluation of their expression in biological matrices and to their utility as biomarkers of BC development.

摘要

膀胱癌（BC）是全球第九大常见癌症，在男性中是第六大常见癌症。其发展与慢性炎症、遗传易感性、吸烟、职业暴露和环境污染物有关。这项工作的目的是通过计算网络方法识别膀胱癌中受环境或砷暴露调节的基因/蛋白质子网络。我们的研究证明，在“膀胱癌与环境”和“膀胱癌与砷化合物”网络中均存在枢纽节点。这些枢纽节点与昼夜节律基因相关，并且已被报道参与膀胱癌的一些微小RNA靶向，因此表明它们如何在因环境或砷暴露导致的膀胱癌发展中发挥重要作用。通过与已识别的枢纽节点对生存的假定影响相关的数据挖掘分析，我们确定了基因/蛋白质及其突变，进一步开展与其在生物基质中的表达评估以及作为膀胱癌发展生物标志物的效用相关的实验研究将聚焦于这些基因/蛋白质及其突变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/bec56970e8fd/oncotarget-08-65240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/a79b792ce8fd/oncotarget-08-65240-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/358f14a9bd6b/oncotarget-08-65240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/f40e3035ce20/oncotarget-08-65240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/e685e4edbc29/oncotarget-08-65240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/bec56970e8fd/oncotarget-08-65240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/a79b792ce8fd/oncotarget-08-65240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/a5bf1bdafbfe/oncotarget-08-65240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/358f14a9bd6b/oncotarget-08-65240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/f40e3035ce20/oncotarget-08-65240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/e685e4edbc29/oncotarget-08-65240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8aa/5630327/bec56970e8fd/oncotarget-08-65240-g006.jpg

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