肝白血病相关巨噬细胞在Notch1诱导的急性T细胞白血病中表现出促炎表型。
Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia.
作者信息
Yang Xiao, Feng Wenli, Wang Rong, Yang Feifei, Wang Lina, Chen Shayan, Chen Chong, Ren Qian, Zheng Guoguang
机构信息
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China; Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Immunobiology. 2018 Jan;223(1):73-80. doi: 10.1016/j.imbio.2017.10.009. Epub 2017 Oct 4.
Tumor-associated macrophages (TAMs) are well accepted and the pathological role of macrophages in hematopoietic malignancies have been proposed. Hepatomegaly is frequently observed in T cell acute lymphoblastic leukemia (T-ALL) patients with poor prognosis. However, the role of leukemia-associated macrophages (LAMs) in hepatic microenvironment remains unclear. Here, the characteristics of hepatic LAMs (H-LAMs) were studied in Notch1 induced T-ALL model. Increase in proportion and absolute counts of H-LAMs was detected with infiltration of inflammatory cells. Furthermore, H-LAMs exhibited a more M1-like phenotype distinct from that of TAMs in hepatocellular carcinoma and LAMs from BM or spleen in leukemia. Moreover, H-LAMs expressed increased level of cytokines in charge of recruiting inflammatory cells, which contributed to pro-inflammatory hepatic microenvironment.
肿瘤相关巨噬细胞（TAM）已被广泛认可，并且巨噬细胞在造血系统恶性肿瘤中的病理作用也已被提出。肝肿大在预后较差的T细胞急性淋巴细胞白血病（T-ALL）患者中经常可见。然而，白血病相关巨噬细胞（LAM）在肝脏微环境中的作用仍不清楚。在此，我们在Notch1诱导的T-ALL模型中研究了肝脏LAM（H-LAM）的特征。随着炎性细胞浸润，检测到H-LAM的比例和绝对数量增加。此外，H-LAM表现出一种更类似M1的表型，这与肝细胞癌中的TAM以及白血病中来自骨髓或脾脏的LAM不同。而且，H-LAM表达负责招募炎性细胞的细胞因子水平增加，这有助于形成促炎性肝脏微环境。
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