Weis Susanne, Hodgetts Sophie, Hausmann Markus
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany; Department of Psychology, Durham University, UK; Durham University Neuroimaging Centre (DUNIC), UK.
Department of Psychology, Durham University, UK; Durham University Neuroimaging Centre (DUNIC), UK.
Brain Cogn. 2019 Apr;131:66-73. doi: 10.1016/j.bandc.2017.09.003. Epub 2017 Oct 10.
It has not yet been established if resting state (RS) connectivity reflects stable characteristics of the brain, or if it is modulated by the psychological and/or physiological state of the participant. Based on research demonstrating sex hormonal effects in task-related brain activity, the present study aimed to investigate corresponding differences in RS networks. RS functional Magnetic Resonance Imaging (RS fMRI) was conducted in women during three different menstrual cycle phases, while men underwent three repeated RS fMRI testing sessions. Independent component analysis was used to identify the default mode network (DMN) and an auditory RS network. For the DMN, RS connectivity was stable across testing sessions in men, but varied across the menstrual cycle in women. For the auditory network (AN), retest reliable sex difference was found. Although RS activity in the DMN has been interpreted as trait characteristic of functional brain organization, these findings suggest that RS activity in networks involving frontal areas might be less stable than in sensory-based networks and can dynamically fluctuate. This also implies that some of the previously reported effects of sex hormones on task-related activity might to some extent be mediated by cycle-related fluctuations in RS activity, especially when frontal areas are involved.
静息态（RS）连接性是否反映大脑的稳定特征，或者它是否受参与者的心理和/或生理状态调节，目前尚无定论。基于显示性激素对任务相关脑活动有影响的研究，本研究旨在调查RS网络中的相应差异。对处于三个不同月经周期阶段的女性进行了静息态功能磁共振成像（RS fMRI），而男性则进行了三次重复的RS fMRI测试。使用独立成分分析来识别默认模式网络（DMN）和听觉RS网络。对于DMN，男性在测试过程中RS连接性稳定，而女性在月经周期中则有所变化。对于听觉网络（AN），发现了重测可靠的性别差异。尽管DMN中的RS活动被解释为功能性脑组织的特质特征，但这些发现表明，涉及额叶区域的网络中的RS活动可能不如基于感觉的网络稳定，并且可能会动态波动。这也意味着，先前报道的性激素对任务相关活动的一些影响可能在一定程度上由RS活动的周期相关波动介导，尤其是当涉及额叶区域时。
