文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

灼口综合征性别差异的雌激素介导神经机制

Estrogen-Mediated Neural Mechanisms of Sex Differences in Burning Mouth Syndrome.

作者信息

Nagamine Takahiko

机构信息

Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi 747-0066, Japan.

Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan.

出版信息

Neurol Int. 2025 Apr 20;17(4):61. doi: 10.3390/neurolint17040061.

DOI:10.3390/neurolint17040061
PMID:40278432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12030133/
Abstract

BACKGROUND/OBJECTIVES: Burning mouth syndrome (BMS) is a chronic pain disorder of the oral cavity in the absence of organic disease and is prevalent among menopausal women. Estrogen may be involved in the formation of nerves involved in pain. METHODS: This paper presents an inferred mechanism for the relationship between estrogen and BMS based on a synthesis and interpretation of findings from a selection of published studies. RESULTS: Estrogen influences the formation of neural circuits in BMS by dividing the complex pain circuit into the following three components: the peripheral pain circuit, brain network pain circuit, and memorized pain circuit. CONCLUSIONS: The development of BMS may be influenced by the formation of neural circuits by sex hormones.

摘要

背景/目的：灼口综合征（BMS）是一种无器质性疾病的口腔慢性疼痛障碍，在绝经后女性中普遍存在。雌激素可能参与疼痛相关神经的形成。 方法：本文基于对一系列已发表研究结果的综合与解读，提出了雌激素与灼口综合征之间关系的推断机制。 结果：雌激素通过将复杂的疼痛回路分为以下三个部分来影响灼口综合征中神经回路的形成：外周疼痛回路、脑网络疼痛回路和记忆性疼痛回路。 结论：灼口综合征的发展可能受性激素神经回路形成的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/1822641eab6a/neurolint-17-00061-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/c961a3d7b784/neurolint-17-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/3e9089f5c3e7/neurolint-17-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/cf418389b957/neurolint-17-00061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/a415587877f0/neurolint-17-00061-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/3c71a6dc7025/neurolint-17-00061-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/1822641eab6a/neurolint-17-00061-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/c961a3d7b784/neurolint-17-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/3e9089f5c3e7/neurolint-17-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/cf418389b957/neurolint-17-00061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/a415587877f0/neurolint-17-00061-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/3c71a6dc7025/neurolint-17-00061-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcc9/12030133/1822641eab6a/neurolint-17-00061-g006.jpg

相似文献

[1]
Estrogen-Mediated Neural Mechanisms of Sex Differences in Burning Mouth Syndrome.

Neurol Int. 2025-4-20

[2]
Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome.

J Dent Sci. 2022-1

[3]
Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with burning mouth syndrome: Results from a pilot study.

J Oral Pathol Med. 2017-12-11

[4]
Altered structure and function in the hippocampus and medial prefrontal cortex in patients with burning mouth syndrome.

Pain. 2014-4-24

[5]
An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives.

J Oral Rehabil. 2019-4-10

[6]
Association of somatosensory dysfunction with symptom duration in burning mouth syndrome.

Clin Oral Investig. 2018-12-19

[7]
Interventions for the treatment of burning mouth syndrome.

Cochrane Database Syst Rev. 2001

[8]
Is Burning Mouth Syndrome a Neuropathic Pain Disorder? A Systematic Review.

J Oral Facial Pain Headache.

[9]
Conditioned Pain Modulation Differences in Central and Peripheral Burning Mouth Syndrome (BMS) Patients.

J Oral Rehabil. 2025-4

[10]
Candidiasis and Other Bacterial Infections among Patients Diagnosed with Burning Mouth Syndrome.

Medicina (Kaunas). 2022-8-1

引用本文的文献

[1]
Role of Brain Networks in Burning Mouth Syndrome: A Narrative Review.

Dent J (Basel). 2025-7-4

[2]
Potential Target Receptors for the Pharmacotherapy of Burning Mouth Syndrome.

Pharmaceuticals (Basel). 2025-6-14

本文引用的文献

[1]
Pathogenesis of Orofacial Pain Based on Brain Circuits.

Oral Dis. 2025-2-27

[2]
Molecular Mechanisms of Pain Regulation by Sex Hormones in Individuals With Burning Mouth Syndrome.

J Oral Rehabil. 2025-5

[3]
Sexual hormones changes in burning mouth syndrome: A systematic review.

J Oral Rehabil. 2024-11

[4]
Chronic orofacial pain.

Br Dent J. 2024-8

[5]
Pathology of pain and its implications for therapeutic interventions.

Signal Transduct Target Ther. 2024-6-8

[6]
Nociceptors are functionally male or female: from mouse to monkey to man.

Brain. 2024-12-3

[7]
The Role of the Insula in Chronic Pain and Associated Structural Changes: An Integrative Review.

Cureus. 2024-4-18

[8]
Clinical and epidemiological profile of burning mouth syndrome patients following the International Headache Society classification: a systematic review and meta-analysis.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2024-2

[9]
Burning mouth syndrome needs to consider the gut-brain axis from three types of pain: nociceptive, neuropathic, and nociplastic pain.

J Gastrointestin Liver Dis. 2023-12-22

[10]
Topical gabapentin solution for the management of burning mouth syndrome: A retrospective study.

PLoS One. 2023

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索