生长抑素对人血小板聚集的体外增强作用。
In vitro enhancement of human platelet aggregation by somatostatin.
作者信息
Gazzaniga P P, Di Macco G, La Mancusa R, Oddi A, Pappalardo G, Pulcinelli F M, Reggio D
机构信息
Department of Experimental Medicine, University of Rome La Sapienza, Italy.
出版信息
Experientia. 1988 Oct 15;44(10):892-4. doi: 10.1007/BF01941192.
Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets.
在富含人血小板的血浆和凝胶过滤血小板制剂中，极低浓度的生长抑素（S - 14）能显著增强由胶原蛋白、瑞斯托霉素和花生四烯酸诱导的体外聚集作用，但不能增强由二磷酸腺苷（ADP）或肾上腺素诱导的聚集作用。脱敏现象可通过重复添加S - 14或S - 14与血小板的长时间接触诱导产生。
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