Matsumoto Yusuke, Ohta Keisuke, Nishio Machiko
Department of Microbiology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
Arch Virol. 2018 Jan;163(1):219-222. doi: 10.1007/s00705-017-3580-1. Epub 2017 Oct 14.
Hazara virus (HAZV) is a member of the genus Orthonairovirus of the family Nairoviridae. HAZV is closely related to Crimean-Congo hemorrhagic fever virus but differs in that it is non-pathogenic to humans. To establish an infection model system, we tested whether embryonated chicken eggs, which are classically used for evaluating viral pathogenicity, are susceptible to HAZV infection. We demonstrated that HAZV replicates well in embryonated chicken eggs and kills 100% of the embryos. This can be a valuable tool to evaluate the lethality of nairoviruses in a biosafety level 2 laboratory.
哈扎拉病毒（HAZV）是内罗病毒科正内罗病毒属的成员。HAZV与克里米亚-刚果出血热病毒密切相关，但不同之处在于它对人类无致病性。为建立一个感染模型系统，我们测试了传统上用于评估病毒致病性的鸡胚是否易受HAZV感染。我们证明HAZV能在鸡胚中良好复制，并导致100%的胚胎死亡。这可以成为在生物安全2级实验室中评估内罗病毒致死性的一个有价值的工具。
