Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA, 94305, USA.
Curr Cardiol Rep. 2017 Oct 13;19(11):118. doi: 10.1007/s11886-017-0915-1.
Acute rejection is one of the most feared complications of cardiac transplantation. Developing non-invasive methods for detection and surveillance of acute rejection have long been a goal for post-transplant care.
Here, we will review molecular diagnostic tests that are currently in use or under development to diagnose acute cellular rejection after cardiac transplantation. Gene expression, microRNA, molecular microscope, and cell-free DNA assays offer non-invasive alternatives to the endomyocardial biopsy for acute rejection surveillance.
急性排斥反应是心脏移植后最令人恐惧的并发症之一。长期以来，人们一直致力于开发非侵入性方法来检测和监测急性排斥反应，以用于移植后护理。
在这里，我们将回顾目前用于诊断心脏移植后急性细胞排斥反应的分子诊断检测方法。基因表达、microRNA、分子显微镜和无细胞 DNA 检测为急性排斥反应监测提供了一种替代心内膜活检的非侵入性方法。
