Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Magn Reson Med. 2018 Jun;79(6):2923-2934. doi: 10.1002/mrm.26952. Epub 2017 Oct 13.
To assess the reproducibility of O MRI-based determination of the cerebral metabolic rate of oxygen consumption (CMRO ) in healthy volunteers. To assess the influence of image acquisition and reconstruction parameters on dynamic quantification of functional parameters such as CMRO .
Dynamic O MRI data were simulated and used to investigate influences of temporal resolution (Δt) and partial volume correction (PVC) on the determination of CMRO . Three healthy volunteers were examined in two separate examinations. In vivo O MRI measurements were conducted with a nominal spatial resolution of (7.5 mm) using a density-adapted radial sequence with golden angle acquisition scheme. In each measurement, 4.0 ± 0.1 L of 70%-enriched O gas were administered using a rebreathing system. Data were corrected with a PVC algorithm, and CMRO was determined in gray matter (GM) and white matter (WM) compartments using a three-phase metabolic model (baseline, O inhalation, decay phase).
Comparison with the ground truth of simulations revealed improved CMRO determination after application of PVC and with Δt ≤ 2:00 min. Evaluation of in vivo data yields to CMRO = 2.31 ± 0.1 μmol/g/min and to CMRO = 0.69 ± 0.04 μmol/g/min with coefficients of variation (CoV) of 0.3-5.5% and 4.3-5.0% for intra-volunteer and inter-volunteer data, respectively.
This in vivo O inhalation study demonstrated that the proposed experimental setup enables reproducible determination of CMRO in healthy volunteers. Magn Reson Med 79:2923-2934, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
评估基于 O 磁共振成像（MRI）的健康志愿者脑氧代谢率（CMRO ）的可重复性。评估图像采集和重建参数对功能参数（如 CMRO ）的动态定量的影响。
模拟动态 O MRI 数据，以研究时间分辨率（Δt）和部分体积校正（PVC）对 CMRO 测定的影响。在两次单独的检查中对 3 名健康志愿者进行了检查。使用具有黄金角采集方案的密度自适应径向序列，以（7.5mm）的名义空间分辨率进行体内 O MRI 测量。在每次测量中，使用再呼吸系统给予 4.0±0.1L 的 70%富集 O 气体。使用 PVC 算法校正数据，并使用三相代谢模型（基线、O 吸入、衰减阶段）在灰质（GM）和白质（WM）区室中确定 CMRO。
与模拟的地面实况相比，应用 PVC 后并在 Δt≤2：00min 时，CMRO 的测定得到了改善。对体内数据的评估得出 CMRO=2.31±0.1μmol/g/min 和 CMRO=0.69±0.04μmol/g/min，志愿者内和志愿者间数据的变异系数（CoV）分别为 0.3-5.5%和 4.3-5.0%。
这项 O 吸入体内研究表明，所提出的实验设置能够在健康志愿者中可重复地测定 CMRO。磁共振医学 79：2923-2934，2018。©2017 国际磁共振学会。
