Ebersberger Louise, Kratzer Fabian J, Potreck Arne, Niesporek Sebastian C, Keymling Myriam, Nagel Armin M, Bendszus Martin, Wick Wolfgang, Ladd Mark E, Schlemmer Heinz-Peter, Hoffmann Angelika, Platt Tanja, Paech Daniel
Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
Front Neurosci. 2023 Jun 15;17:1186558. doi: 10.3389/fnins.2023.1186558. eCollection 2023.
Dynamic oxygen-17 (O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic O MRI was applied during O inhalation in a patient with early subacute stroke. The analysis of the relative O water (HO) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.
动态氧-17（¹⁷O）磁共振成像（MRI）是一种成像方法，它能够通过三相吸入实验对脑氧代谢进行直接且无创的评估，从而有可能区分存活组织和非存活组织。本研究的目的是首次在7特斯拉（T）场强下对一名中风患者进行动态¹⁷O MRI检查。在这个概念验证实验中，对一名处于早期亚急性期中风的患者在吸入¹⁷O期间进行了动态¹⁷O MRI检查。将患侧中风区域与对侧健康区域的相对¹⁷O水（H₂¹⁷O）信号进行分析，结果显示无显著差异。然而，¹⁷O MRI的技术可行性已得到证实，为未来神经血管疾病的研究铺平了道路。
