动态氧-17磁共振成像于7特斯拉在一名早期亚急性中风患者中的首次应用。
First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke.
作者信息
Ebersberger Louise, Kratzer Fabian J, Potreck Arne, Niesporek Sebastian C, Keymling Myriam, Nagel Armin M, Bendszus Martin, Wick Wolfgang, Ladd Mark E, Schlemmer Heinz-Peter, Hoffmann Angelika, Platt Tanja, Paech Daniel
机构信息
Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
出版信息
Front Neurosci. 2023 Jun 15;17:1186558. doi: 10.3389/fnins.2023.1186558. eCollection 2023.
Dynamic oxygen-17 (O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic O MRI was applied during O inhalation in a patient with early subacute stroke. The analysis of the relative O water (HO) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.
动态氧-17（¹⁷O）磁共振成像（MRI）是一种成像方法，它能够通过三相吸入实验对脑氧代谢进行直接且无创的评估，从而有可能区分存活组织和非存活组织。本研究的目的是首次在7特斯拉（T）场强下对一名中风患者进行动态¹⁷O MRI检查。在这个概念验证实验中，对一名处于早期亚急性期中风的患者在吸入¹⁷O期间进行了动态¹⁷O MRI检查。将患侧中风区域与对侧健康区域的相对¹⁷O水（H₂¹⁷O）信号进行分析，结果显示无显著差异。然而，¹⁷O MRI的技术可行性已得到证实，为未来神经血管疾病的研究铺平了道路。
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