Marchini G, Lagercrantz H, Milerad J, Winberg J, Uvnäs-Moberg K
Department of Paediatrics, Karolinska Hospital, Stockholm, Sweden.
J Pediatr Gastroenterol Nutr. 1988 Sep-Oct;7(5):641-4. doi: 10.1097/00005176-198809000-00003.
Sick neonates often have a disturbed gastrointestinal motility. As somatostatin inhibits various gastrointestinal functions, we investigated whether or not somatostatin levels are high in sick infants. Somatostatin and gastrin levels were measured in plasma samples collected from sick and healthy neonates. Somatostatin levels were found to be significantly elevated in sick infants when compared to healthy ones, both term (91 versus 5 pM) and preterm (35 versus 5 pM). We suggest that the gastrointestinal symptoms seen in infants during illness may be related to an enhanced secretion of gastric somatostatin.
患病新生儿常伴有胃肠动力紊乱。由于生长抑素会抑制多种胃肠功能，我们研究了患病婴儿体内的生长抑素水平是否偏高。我们检测了患病新生儿和健康新生儿血浆样本中的生长抑素和胃泌素水平。结果发现，与健康新生儿相比，患病婴儿（足月儿：91皮摩尔对5皮摩尔；早产儿：35皮摩尔对5皮摩尔）的生长抑素水平显著升高。我们认为，患病婴儿出现的胃肠道症状可能与胃内生长抑素分泌增加有关。
