Marchini G, Lagercrantz H, Feuerberg Y, Winberg J, Uvnäs-Moberg K
Acta Paediatr Scand. 1987 Jul;76(4):573-8. doi: 10.1111/j.1651-2227.1987.tb10523.x.
The aim of the present investigation was to study the effect of non-nutritive sucking on plasma levels of insulin, gastrin, and somatostatin in infants. These hormones were measured with radioimmunoassay in plasma collected from fullterm and preterm infants sucking a pacifier. In fullterm infants, sucking caused a significant increase of insulin levels from 13 +/- 10 microU/ml to 40 +/- 36 microU/ml and 21 +/- 17 microU/ml after 45 sec and 5 min respectively, from when the infants started sucking. A similar pattern was seen in preterm infants. In contrast, gastrin and somatostatin levels were not significantly affected. We suggest that sucking causes an activation of the vagal nerve, which results in the release of insulin. We also suggest that in infants, oral feeding is superior to bolus feeding, since in the latter case no vagal activation and consequently no release of hormones with anabolic properties occurs.
本研究的目的是探讨非营养性吸吮对婴儿血浆胰岛素、胃泌素和生长抑素水平的影响。采用放射免疫分析法测定足月和早产婴儿吸吮安抚奶嘴时采集的血浆中这些激素的水平。在足月婴儿中，吸吮导致胰岛素水平显著升高，分别在婴儿开始吸吮后45秒和5分钟时，胰岛素水平从13±10微单位/毫升升至40±36微单位/毫升和21±17微单位/毫升。早产婴儿也出现类似情况。相比之下，胃泌素和生长抑素水平未受到显著影响。我们认为吸吮会激活迷走神经，从而导致胰岛素释放。我们还认为，在婴儿中，经口喂养优于推注喂养，因为在后一种情况下不会激活迷走神经，因此不会释放具有合成代谢特性的激素。
