1Department of Clinical & Health Psychology,College of Public Health & Health Professions,University of Florida,Gainesville,Florida.
3Department of Psychiatry & Biobehavioral Sciences,David Geffen School of Medicine,University of California - Los Angeles,Los Angeles,California.
J Int Neuropsychol Soc. 2018 Mar;24(3):269-282. doi: 10.1017/S1355617717001011. Epub 2017 Oct 16.
Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD.
A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy ("pure" depressive symptoms, "pure" apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function.
After adjusting for general cognitive status and the influence of the other symptom dimensions, "pure" depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite.
Findings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269-282).
抑郁和淡漠单独或联合存在都会对帕金森病（PD）患者的认知产生负面影响。然而，抑郁和淡漠的特定症状维度对认知的影响尚不清楚。本研究根据 Kirsch-Darrow 等人（2011 年）确定的因素，调查了 PD 患者的抑郁和淡漠症状维度与记忆和执行功能之间的关系。
138 名非痴呆 PD 患者（平均年龄=64.51±7.43 岁）接受了神经心理学测试，并完成了贝克抑郁量表第二版和淡漠量表。单独的分层回归模型检验了抑郁和淡漠的症状维度（“纯”抑郁症状、“纯”淡漠、兴趣/快感丧失（快感缺失）和躯体症状）与三个认知域综合表现：即时言语记忆、延迟言语记忆和执行功能之间的关系。
在调整了一般认知状态和其他症状维度的影响后，“纯”抑郁症状与延迟言语记忆综合表现呈负相关（p<.034），躯体症状与执行功能综合表现呈正相关（p<.026）。没有症状维度与即时言语记忆综合表现显著相关。
研究结果表明，特定的情绪症状与非痴呆 PD 患者的延迟言语记忆和执行功能表现相关。需要进一步研究以更好地理解抑郁和淡漠的特定症状维度与 PD 认知相关的可能机制。（JINS，2018，24，269-282）。
