Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA.
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, USA.
Psychiatry Res Neuroimaging. 2017 Feb 28;260:70-75. doi: 10.1016/j.pscychresns.2016.12.008. Epub 2016 Dec 16.
Differences in brain volumes have commonly been reported in older adults with both subthreshold and major depression. Few studies have examined the association between specific symptom dimensions of depression and brain volumes. This study used vertex-wise analyses to examine the association between specific symptom dimensions of depression and brain volumes in older adults with subthreshold levels of depressive symptoms. Forty-three community-dwelling adults between the ages of 55 and 81 years underwent a structural Magnetic Resonance Imaging scan and completed the Center for Epidemiologic Studies Depression Scale (CES-D). Vertex-wise analyses were conducted using Freesurfer Imaging Suite to examine the relationship between CES-D subscale scores and gray matter volumes while controlling for sex, age, and education. We found distinct associations between depressed mood, somatic symptoms, and lack of positive affect subscales with regional volumes, including primarily positive relationships in temporal regions and a negative association with the lingual gyrus. The relationship between higher depressed mood subscale scores and larger volumes in the left inferior temporal lobe withstood Monte-Carlo correction for multiple comparisons. Results from this preliminary study highlight the importance of examining depression on a symptom dimension level and identify brain regions that may be important in larger studies of depression.
在有亚临床和重度抑郁的老年人中，大脑体积的差异通常有报道。很少有研究检查抑郁的特定症状维度与大脑体积之间的关系。本研究使用顶点分析来检查亚临床抑郁症状老年人中抑郁特定症状维度与大脑体积之间的关系。43 名年龄在 55 岁至 81 岁之间的社区居民接受了结构磁共振成像扫描，并完成了流行病学研究抑郁量表（CES-D）。使用 Freesurfer 成像套件进行顶点分析，以检查 CES-D 子量表得分与灰质体积之间的关系，同时控制性别、年龄和教育。我们发现抑郁情绪、躯体症状和缺乏积极情绪子量表与区域体积之间存在明显的关联，包括颞叶区域的主要正相关关系和与舌回的负相关关系。在颞叶左下方的下颞叶体积与较高的抑郁情绪子量表评分之间存在关联，这一结果在蒙特卡罗多重比较校正后仍然成立。这项初步研究的结果强调了在症状维度层面上检查抑郁的重要性，并确定了在更大的抑郁研究中可能重要的大脑区域。
