Department of Psychology and Cognitive Science, University of Trento, Italy; Mobile and Social Computing Lab, Fondazione Bruno Kessler, Trento, Italy.
Division of Psychology, School of Social Sciences, Nanyang Technological University, Singapore.
Res Dev Disabil. 2018 Nov;82:27-38. doi: 10.1016/j.ridd.2017.10.007. Epub 2017 Oct 21.
Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword "OXTR" before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total. The papers were catalogued in a database and filtered for gene-environment interaction, psychiatric disorders and involvement of parental care. In particular, rs53576 and rs2254298 were found to be significantly involved in gene-environment interactions that modulated risk for psychopathology and the following psychiatric disorders: disruptive behavior, depression, anxiety, eating disorder and borderline personality disorder. These results illustrate the importance of OXTR in mediating the impact of parental care on the emergence of psychopathology.
催产素在典型和非典型环境下的社会行为调节中起着重要作用。此外，早期父母养育的质量为长期的社会心理发展奠定了基础。在这里，我们回顾了研究催产素受体 (OXTR) 如何与早期父母养育经历相互作用，从而影响精神疾病发展的研究。我们使用 Pubmed、Scopus 和 PsycInfo 数据库，在搜索特定的 OXTR 单核苷酸多态性 (SNP) 之前使用了关键字“OXTR”，总共生成了 598 项研究。这些论文被编制成一个数据库，并根据基因-环境相互作用、精神疾病和父母养育的参与情况进行了筛选。特别是，rs53576 和 rs2254298 被发现与调节精神病理学风险的基因-环境相互作用显著相关，以及以下精神障碍：破坏性行为、抑郁、焦虑、饮食障碍和边缘型人格障碍。这些结果说明了 OXTR 在介导父母养育对精神病理学出现的影响中的重要性。
