Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, ES-41013 Seville, Spain.
Schizophr Res. 2018 May;195:142-148. doi: 10.1016/j.schres.2017.10.012. Epub 2017 Oct 21.
This study aimed to explore the possible independent associations of sedentary behaviour (SB), physical activity (PA), and cardiorespiratory fitness (CRF) with clustered (CCRS) and individual cardiometabolic risk (waist circumference [waist], systolic/diastolic blood pressure, triglycerides, high-density lipoprotein-cholesterol, and fasting blood glucose) in patients with psychosis. In 43 outpatients with psychosis (mean age±SD: 42.3±8.5years, 86% men), SB and light, moderate-to-vigorous, and total PA were measured with the SenseWear Pro3 Armband, and CRF with the 6-minute walking test. Multiple linear regression models adjusted for multiple confounders were applied. High SB, low PA and low CRF levels were associated with an unfavourable cardiometabolic risk profile (increased presence of metabolic syndrome and number of cardiometabolic abnormalities, as well as worse values and elevated presence of abnormalities for all individual cardiometabolic risk factors). SB was associated with CCRS, number of cardiometabolic abnormalities, waist, and fasting blood glucose (all p<0.05). After adjusting for PA and CRF, waist and fasting blood glucose remained significant. Light PA was associated with waist, moderate-to-vigorous PA with CCRS, and total PA with CCRS and waist (all p<0.05). These results became non-significant after adjusting for SB and CRF. CRF was associated with CCRS, waist, and systolic blood pressure (all p<0.05). The associations with CCRS and waist remained significant after adjusting for SB and PA. Together, these results suggest the importance of considering SB and CRF, regardless PA, in the prevention and treatment of cardiometabolic disorders among patients with psychosis.
本研究旨在探讨久坐行为（SB）、体力活动（PA）和心肺功能（CRF）与精神障碍患者的心血管代谢风险综合指标（CCRS）和个体心血管代谢风险（腰围[waist]、收缩压/舒张压、甘油三酯、高密度脂蛋白胆固醇和空腹血糖）之间可能存在的独立关联。在 43 名精神障碍门诊患者（平均年龄±标准差：42.3±8.5 岁，86%为男性）中，使用 SenseWear Pro3 臂带测量 SB 和轻、中-剧烈、以及总 PA，使用 6 分钟步行试验测量 CRF。应用多元线性回归模型调整了多个混杂因素。高 SB、低 PA 和低 CRF 水平与不良的心血管代谢风险特征相关（代谢综合征的发生率增加，心血管代谢异常的数量增加，以及所有个体心血管代谢危险因素的指标值更差，异常的发生率更高）。SB 与 CCRS、心血管代谢异常的数量、腰围和空腹血糖有关（均 p<0.05）。在调整了 PA 和 CRF 后，腰围和空腹血糖仍有统计学意义。轻 PA 与腰围有关，中-剧烈 PA 与 CCRS 有关，总 PA 与 CCRS 和腰围有关（均 p<0.05）。在调整了 SB 和 CRF 后，这些关联变得无统计学意义。CRF 与 CCRS、腰围和收缩压有关（均 p<0.05）。在调整了 SB 和 PA 后，与 CCRS 和腰围的关联仍然显著。总之，这些结果表明，在预防和治疗精神障碍患者的心血管代谢紊乱时，无论 PA 如何，都应考虑 SB 和 CRF。
