Köroğlu Reyhan, Köksal İsmail, Şimşek Fikri Selçuk, Gezer Fatma, Kekilli Ersoy, Ünal Bülent
Department of Nuclear Medicine, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Department of Nuclear Medicine, Malatya State Hospital, Malatya, Turkey.
World J Nucl Med. 2017 Oct-Dec;16(4):275-280. doi: 10.4103/1450-1147.215485.
It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of F-fluoro-2-deoxy-D-glucose (F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1 h (PET-1) and in the 2 h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2,, RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely.
本研究旨在探讨最大标准化摄取值（SUVmax）、平均标准化摄取值（SUVmean）和滞留指数（RI）之间的相关性，这些指标代表了正电子发射断层扫描（PET）中使用的F-氟-2-脱氧-D-葡萄糖（F-FDG）摄取的定量评估，以及临床病理和生物学预后因素。本研究纳入了41例经组织病理学诊断的乳腺癌女性患者。所有患者在进行PET/计算机断层扫描（CT）前均接受新辅助化疗。注射FDG后，在1小时内（PET-1）和2小时内（PET-2）进行PET/CT筛查。对每个图像的SUVmax、SUVmean、SUVmax RI和SUVmean RI进行定性和半定量计算。评估了PET定量和半定量参数与生物学及临床病理预后因素之间的相关性。统计学上，通过临床影像、临床分期以及组织病理学评估的淋巴结（LNs）与PET定量参数（SUVmax1、SUVmax2、RImax、SUVmean1、SUVmean2、RImean）之间存在显著正相关（P < 0.05）。虽然仅通过LN（组织病理学）检测到与RImax存在统计学显著相关性，但通过临床影像、临床分期、代谢分期和LN（组织病理学）检测到与RImean存在相关性。在组织病理学诊断为浸润性导管癌的患者（n = 34）中，RImax与雌激素受体之间存在统计学显著相关性（P < 0.05）。我们在乳腺癌中检测到生物学和临床病理预后因素与SUVmax以及SUVmean值之间的相关性。即使SUVmean值未被常规使用，但在研究预后因素与PET参数之间的相关性时，其可能提供重要信息。
