急性给予胰岛素样生长因子I对拉伦型侏儒症患者的影响。
Effect of acute administration of insulin-like growth factor I in patients with Laron-type dwarfism.
作者信息
Laron Z, Klinger B, Erster B, Anin S
机构信息
Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
出版信息
Lancet. 1988 Nov 19;2(8621):1170-2. doi: 10.1016/s0140-6736(88)90236-x.
Biosynthetic insulin-type growth factor I (IGF-I) was given as an intravenous bolus of 75 micrograms/kg to 9 patients with Laron-type dwarfism. Rapid onset of hypoglycaemia (-45% of basal level) was associated with a reduction in plasma insulin (-55% of basal level); thus, the lack of growth hormone receptors in this condition does not apply to IGF-I receptors and post-receptor pathways. Long-term treatment may therefore be beneficial in Laron-type dwarfism.
给9名拉伦型侏儒症患者静脉推注生物合成胰岛素样生长因子I（IGF-I），剂量为75微克/千克。低血糖迅速发作（降至基础水平的-45%）与血浆胰岛素降低（降至基础水平的-55%）相关；因此，这种情况下生长激素受体的缺乏并不适用于IGF-I受体和受体后途径。因此，长期治疗可能对拉伦型侏儒症有益。
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