Bajpai Anurag, Menon P S N
Department of Endocrinology and Diabetes, Center for Hormone Research, Royal Children's Hospital, Melbourne, Victoria, Australia.
Indian J Pediatr. 2006 Jan;73(1):67-71. doi: 10.1007/BF02758264.
The growth hormone-insulin like growth factor (GH-IGF) axis plays a crucial role in the regulation of growth. Initially considered to be a mediator of growth hormone actions, IGF axis has been established as an independent endocrine system with wide array of actions. Recent advances have led to tremendous increase in the clinical utility of the IGF axis. IGF-based investigations (IGF1 and IGF binding protein 3) are now replacing GH-based investigations for evaluation and monitoring of disorders of the GH-IGF axis. IGF therapy has been successfully utilized in growth hormone insensitivity syndrome and GHD type 1B. The possibility of IGF axis as therapeutic options is being explored in wide variety of disorders like hypoxic-ischemic encephalopathy, Alzheimer's disease and psoriasis.
生长激素-胰岛素样生长因子（GH-IGF）轴在生长调节中起关键作用。胰岛素样生长因子轴最初被认为是生长激素作用的介质，现已确立为一个具有广泛作用的独立内分泌系统。最近的进展极大地提高了胰岛素样生长因子轴的临床应用价值。基于胰岛素样生长因子的检测（IGF1和胰岛素样生长因子结合蛋白3）现在正在取代基于生长激素的检测，用于评估和监测生长激素-胰岛素样生长因子轴紊乱。胰岛素样生长因子疗法已成功应用于生长激素不敏感综合征和1B型生长激素缺乏症。人们正在多种疾病中探索将胰岛素样生长因子轴作为治疗选择的可能性，如缺氧缺血性脑病、阿尔茨海默病和银屑病。
