Chanaday Natali L, Kavalali Ege T
Department of Neuroscience, University of Texas Southwestern Medical Centre, Dallas, TX, 75390-9111, USA.
F1000Res. 2017 Sep 22;6:1734. doi: 10.12688/f1000research.12072.1. eCollection 2017.
Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of synaptic vesicles. However, the mechanisms by which synaptic vesicles are retrieved and reconstituted after fusion remain unclear. The complex molecular composition of synaptic vesicles renders their rapid biogenesis a daunting task. Therefore, in this context, kiss-and-run type transient fusion of synaptic vesicles with the plasma membrane without loss of their membrane composition and molecular identity remains a viable hypothesis that can account for the fidelity of the synaptic vesicle cycle. In this article, we discuss the biological implications of this problem as well as its possible molecular solutions.
突触小泡循环对于持续且可靠的神经传递至关重要。突触小泡循环的一个关键组成部分是在突触中观察到的突触小泡生物发生过程，该过程维持着突触小泡的分子特性。然而，突触小泡在融合后被回收和重构的机制仍不清楚。突触小泡复杂的分子组成使其快速生物发生成为一项艰巨的任务。因此，在这种情况下，突触小泡与质膜的吻-跑式瞬时融合且不丧失其膜组成和分子特性，仍然是一个可行的假说，该假说可以解释突触小泡循环的保真度。在本文中，我们讨论了这个问题的生物学意义及其可能的分子解决方案。
