Mörgeli Rudolf, Scholtz Kathrin, Kurth Johannes, Treskatsch Sascha, Neuner Bruno, Koch Susanne, Kaufner Lutz, Spies Claudia
Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Visc Med. 2017 Aug;33(4):267-274. doi: 10.1159/000475611. Epub 2017 Aug 11.
Elderly patients suffering from gastrointestinal malignancies are particularly prone to perioperative complications. Elderly patients often present with reduced physiological reserves, and comorbidities can limit treatment options and promote complications. Surgeons and anesthesiologists must be aware of strategies required to deal with this vulnerable subgroup.
We provide a brief review of current and emerging perioperative strategies for the treatment of elderly patients with gastrointestinal malignancies and frequent comorbidities.
Especially in combination with advanced age, the effects of malignancies can be devastating, bringing new health challenges, exacerbating preexisting conditions, and exerting severe psychological strain. An interdisciplinary assessment and process planning provide an ideal setting to identify and prevent potential complications, especially in regards to frailty and cardiovascular risk. In addition, important perioperative considerations are presented, such as malnutrition, fasting, intraoperative neuromonitoring, and hemodynamic control, as well as postoperative early mobilization, pain, and delirium management.
The decisions and interventions made in the perioperative stage can positively influence many intra- and postoperative factors, significantly improving the chances of successful treatment of elderly cancer patients. Appropriate management can help prevent or mitigate complications, secure a quick recovery, and improve short- and long-term outcomes.
患有胃肠道恶性肿瘤的老年患者特别容易出现围手术期并发症。老年患者的生理储备往往会下降,合并症会限制治疗选择并增加并发症的发生几率。外科医生和麻醉医生必须了解应对这一脆弱亚组所需的策略。
我们简要回顾了当前及新兴的针对患有胃肠道恶性肿瘤且合并症频发的老年患者的围手术期治疗策略。
尤其是随着年龄增长,恶性肿瘤的影响可能是毁灭性的,带来新的健康挑战,加剧既往疾病,并造成严重的心理压力。多学科评估和流程规划为识别和预防潜在并发症提供了理想的环境,特别是在虚弱和心血管风险方面。此外,还介绍了重要的围手术期注意事项,如营养不良、禁食、术中神经监测和血流动力学控制,以及术后早期活动、疼痛和谵妄管理。
围手术期做出的决策和采取的干预措施可对许多术中及术后因素产生积极影响,显著提高老年癌症患者成功治疗的几率。适当的管理有助于预防或减轻并发症,确保快速康复,并改善短期和长期预后。