Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
J Cell Physiol. 2018 Apr;233(4):3552-3577. doi: 10.1002/jcp.26212. Epub 2017 Nov 14.
Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non-enzymatic antioxidants are manifestations of aflatoxicosis. Curcuma longa L. (turmeric) is a medicinal plant widely utilized all over the world for culinary and phytomedical purposes. Considering the antioxidant characteristic of curcumin, the main active component of turmeric, this review is intended to critically summarize the available evidence supporting possible effectiveness of curcumin against aflatoxicosis. Curcumin can serve as a promising candidate for attenuation of the adverse consequences of aflatoxicosis, acting mainly through intrinsic antioxidant effects aroused from its structure, modulation of the immune system as reflected by interleukin-1β and transforming growth factor-β, and interfering with AF's biotransformation by cytochrome P450 isoenzymes CYP1A, CYP3A, CYP2A, CYP2B, and CYP2C.
黄曲霉毒素中毒是一种有害的医学病症，由黄曲霉毒素（AFs）或赭曲霉毒素（OTs）引起。这些毒素的污染对肝脏、肾脏、生殖器官以及免疫系统和心血管系统都有不利影响。黄曲霉毒素中毒与活性氧（ROS）的过度产生密切相关，ROS 是氧化和硝化应激反应的关键贡献者，随后会导致脂质、蛋白质、RNA 和 DNA 的损伤。AF 毒性的主要靶器官是肝脏，其中 DNA 加合物、内质网脱粒、肝脂质过氧化物增加、GSH 耗竭、线粒体功能障碍以及酶和非酶抗氧化剂的减少都是黄曲霉毒素中毒的表现。姜黄（姜黄）是一种药用植物，在世界各地广泛用于烹饪和植物医学目的。考虑到姜黄素（ turmeric 的主要活性成分）的抗氧化特性，本综述旨在批判性地总结现有证据，支持姜黄素对抗黄曲霉毒素中毒的可能有效性。姜黄可以作为减轻黄曲霉毒素中毒不良后果的有前途的候选物，主要通过其结构引起的内在抗氧化作用、白细胞介素-1β和转化生长因子-β反映的免疫系统调节以及细胞色素 P450 同工酶 CYP1A、CYP3A、CYP2A、CYP2B 和 CYP2C 对 AF 生物转化的干扰来发挥作用。
