Department of Neurochemistry, National Institute of Mental Health and Neurosciences, #2900, Hosur Road, Bangalore 560 029, Karnataka, India.
Bioorg Med Chem. 2010 Apr 1;18(7):2631-8. doi: 10.1016/j.bmc.2010.02.029. Epub 2010 Feb 20.
Oxidative stress is implicated in mitochondrial dysfunction associated with neurodegeneration in Parkinson's disease (PD). Depletion of the cellular antioxidant glutathione (GSH) resulting in oxidative stress is considered as an early event in neurodegeneration. We previously showed that curcumin, a dietary polyphenol from turmeric induced GSH synthesis in experimental models and protected against oxidative stress. Here we tested the effect of three bioconjugates of curcumin (involving diesters of demethylenated piperic acid, valine and glutamic acid) against GSH depletion mediated oxidative stress in dopaminergic neuronal cells and found that the glutamic acid derivative displayed improved neuroprotection compared to curcumin.
氧化应激与帕金森病（PD）中的神经退行性变相关的线粒体功能障碍有关。细胞抗氧化剂谷胱甘肽 (GSH) 的耗竭导致氧化应激，被认为是神经退行性变的早期事件。我们之前的研究表明，姜黄素是来自姜黄的膳食多酚，可以在实验模型中诱导 GSH 合成并抵抗氧化应激。在这里，我们测试了三种姜黄素的生物缀合物（涉及去亚甲基胡椒酸、缬氨酸和谷氨酸的二酯）对多巴胺能神经元细胞中 GSH 耗竭介导的氧化应激的影响，发现与姜黄素相比，谷氨酸衍生物显示出更好的神经保护作用。
