Elzaki Wail M, Ziada Hassan M, Abubakr Neamat H, Ibrahim Yahia E
Faculty of Dentistry, King Khalid University, Abha, Saudi Arabia.
Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.
Aust Endod J. 2018 Dec;44(3):215-224. doi: 10.1111/aej.12218. Epub 2017 Oct 16.
This study aimed to evaluate the secondary outcomes of gender and arch and their impact on pain reduction following initial endodontic therapy. 185 medications, including placebo were prepared, and 170 participants completed the trial. Group 1, received a single dose of Paracetamol alone (G-1), Group 2 received combined Ibuprofen/Paracetamol (G-2). Group 3 received combined Mefenamic acid/Paracetamol (G-3), group 4 received combined Diclofenac K/Paracetamol (G-4) and Group 5 received a placebo (G-5). There were no statistically significant differences in pain reduction between males and females whilst there were statistically significant differences between them and the placebo group. All combinations of Paracetamol performed better in pain reduction than the placebo among females, while there were no statistically significant differences among males. In conclusion, there were no differences in pain reduction between males and females, and arch for the tested analgesics taken immediately following initial endodontic therapy in teeth with irreversible pulpitis.
本研究旨在评估性别和牙弓的次要结局及其对初次根管治疗后疼痛减轻的影响。制备了包括安慰剂在内的185种药物，170名参与者完成了试验。第1组单独接受单剂量对乙酰氨基酚（G-1），第2组接受布洛芬/对乙酰氨基酚联合用药（G-2）。第3组接受甲芬那酸/对乙酰氨基酚联合用药（G-3），第4组接受双氯芬酸钾/对乙酰氨基酚联合用药（G-4），第5组接受安慰剂（G-5）。男性和女性在疼痛减轻方面无统计学显著差异，而他们与安慰剂组之间存在统计学显著差异。在女性中，对乙酰氨基酚的所有组合在减轻疼痛方面均比安慰剂表现更好，而在男性中则无统计学显著差异。总之，对于患有不可复性牙髓炎的牙齿，在初次根管治疗后立即服用的受试镇痛药，男性和女性以及牙弓在疼痛减轻方面没有差异。
