Menhinick K A, Gutmann J L, Regan J D, Taylor S E, Buschang P H
Private Practice Limited to Endodontics, Washington, DC, USA.
Int Endod J. 2004 Aug;37(8):531-41. doi: 10.1111/j.1365-2591.2004.00836.x.
To compare ibuprofen, to an ibuprofen/acetaminophen combination in managing postoperative pain following root canal treatment. It is hypothesized that the drug combination will provide more postoperative pain relief than the placebo or ibuprofen alone.
Patients presenting at the Texas A&M Baylor College of Dentistry's graduate endodontic clinic, experiencing moderate to severe pain, were considered potential candidates. Fifty-seven patients were included based on established criteria. Following administration of local anaesthesia, a pulpectomy was performed. The patients were administered a single dose of either: (i) placebo; (ii) 600 mg ibuprofen; or (iii) 600 mg ibuprofen and 1000 mg of acetaminophen. Patients recorded pain intensity following treatment on a visual analogue scale and a baseline four-point category pain scale as well as pain relief every hour for the first 4 h then every 2 h thereafter for a total of 8 h. A general linear model (GLM) analysis was used to analyse the outcome.
Based upon the GLM analysis, there was a significant difference between the ibuprofen and the combination drug group, and between placebo and combination drug groups. There was no significant difference between the placebo and the ibuprofen.
The results demonstrate that the combination of ibuprofen with acetaminophen may be more effective than ibuprofen alone for the management of postoperative endodontic pain.
比较布洛芬与布洛芬/对乙酰氨基酚组合在根管治疗术后疼痛管理中的效果。假设该药物组合比安慰剂或单独使用布洛芬能提供更多的术后疼痛缓解。
在德克萨斯农工大学贝勒牙科学院研究生牙髓病诊所就诊、经历中度至重度疼痛的患者被视为潜在候选对象。根据既定标准纳入了57名患者。在局部麻醉给药后，进行了牙髓摘除术。患者被给予单剂量的以下药物之一：（i）安慰剂；（ii）600毫克布洛芬；或（iii）600毫克布洛芬和1000毫克对乙酰氨基酚。患者在治疗后使用视觉模拟量表和基线四分法疼痛量表记录疼痛强度，并在最初4小时内每小时记录一次疼痛缓解情况，此后每2小时记录一次，共记录8小时。使用一般线性模型（GLM）分析来分析结果。
基于GLM分析，布洛芬组与组合药物组之间以及安慰剂组与组合药物组之间存在显著差异。安慰剂组与布洛芬组之间无显著差异。
结果表明，布洛芬与对乙酰氨基酚的组合在管理牙髓病术后疼痛方面可能比单独使用布洛芬更有效。
