Golzari Mohammad Hassan, Hosseini Saeed, Koohdani Fariba, Saboor Yaraghi Ali-Akbar, Javanbakht Mohammad Hassan, Mohammadzadeh-Honarvar Niyaz, Djalali Mahmoud
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2017 Aug;55(8):486-495.
Paraoxonase 1 is known as one of the most important ant oxidative enzymes associated with HDL-c, and because of its antioxidant and antiinflammatory activities. EPA has the antioxidant, anti inflammatory, antithrombogenic, and antiarteriosclerotic properties. Therefore, we investigated the effect of EPA supplementation on the serum levels and activity of PON1 in type 2 diabetic patients. This study was designed as a randomized, double-blind, and placebo-controlled clinical trial. Thirty-six patients with type 2 diabetes were given written; informed consent randomly was classified into 2 groups. They were supplemented with 2 g/day of the capsules of EPA or placebo for eight weeks. Blood sample was given for measurement of the serum levels of lipids, the activity of PON1, FBS and HbA1c. The patients supplemented with EPA showed a significant increase in the serum levels and activity of PON1 and the serum ratio of PON1/HDL-c. There were no significant differences between the two groups regarding any demographic, clinical or biochemical data, total energy intake, and macronutrient intake at the baseline during the intervention, except for a significant increase of protein intake and the levels of HbA1c in the placebo group, and a significant increase of HDL-c, as well as a slight reduction of total cholesterol, LDL-c, TG and FBS in the supplement group. EPA is atheroprotective via increase in the serum levels and activity of PON1, as well as change in the serum levels of lipids, FBS and HbA1c.
对氧磷酶1被认为是与高密度脂蛋白胆固醇相关的最重要的抗氧化酶之一，因其具有抗氧化和抗炎活性。二十碳五烯酸具有抗氧化、抗炎、抗血栓形成和抗动脉粥样硬化特性。因此，我们研究了补充二十碳五烯酸对2型糖尿病患者血清对氧磷酶1水平和活性的影响。本研究设计为一项随机、双盲、安慰剂对照的临床试验。36例2型糖尿病患者签署书面知情同意书后被随机分为2组。他们分别补充2克/天的二十碳五烯酸胶囊或安慰剂，为期8周。采集血样以测定血脂水平、对氧磷酶1活性、空腹血糖和糖化血红蛋白。补充二十碳五烯酸的患者血清对氧磷酶1水平和活性以及对氧磷酶1/高密度脂蛋白胆固醇的血清比值显著升高。两组在任何人口统计学、临床或生化数据、总能量摄入以及干预期间基线时的常量营养素摄入方面均无显著差异，但安慰剂组蛋白质摄入量和糖化血红蛋白水平显著升高，补充组高密度脂蛋白胆固醇显著升高，总胆固醇、低密度脂蛋白胆固醇、甘油三酯和空腹血糖略有降低。二十碳五烯酸通过提高血清对氧磷酶1水平和活性以及改变血脂、空腹血糖和糖化血红蛋白的血清水平来发挥抗动脉粥样硬化作用。
